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Physiological Effects of Androstadienone Exposure

This study has been completed.
Information provided by (Responsible Party):
Rockefeller University Identifier:
First received: November 1, 2007
Last updated: February 16, 2012
Last verified: February 2012
November 1, 2007
February 16, 2012
December 2007
July 2010   (Final data collection date for primary outcome measure)
Skin temperature, skin conductance and salivary cortisol level. [ Time Frame: Monthly over approximately a 5 month period/volunteer ]
Same as current
Complete list of historical versions of study NCT00553384 on Archive Site
The ability to detect odor. [ Time Frame: Monthly over a 5 month period. ]
Same as current
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Not Provided
Physiological Effects of Androstadienone Exposure
Physiological Effects of Androstadienone Exposure

The reason for doing this research is to understand why different people show different responses when they smell an odor called androstadienone. Androstadienone is a chemical found in male sweat. Other studies have shown that smelling this chemical can cause people to experience sweating, changes in skin temperature, and changes in a stress hormone call cortisol. These responses, which are called "physiological effects," are stronger in some people than in others.

We are interested in finding out whether these individual differences are genetic, that is caused by differences in our genes. Humans have about 1000 genes for odorant receptors. These are the molecules that bind and detect odor molecules in our nose and allow us to respond to so many different odors. It has been shown that some of these genes exist in two forms: a functional one and one that has been mutated and is therefore no longer functional.

We think that people who do not respond to a specific odor may carry the non-functional form of the gene for the receptor that detects the odor molecule. To test this idea we want to find people who respond strongly to a specific smell, and compare their odorant receptor genes with those of people who respond weakly to the odor.

The study consists of five visits. The first visit is a screening visit at which the eligibility of the subject is determined and a blood sample is taken. At this visit, the subject is also given ovulation test strips and instructions to perform urine-based ovulation self-tests at home for a period of several days following the onset of menstruation. The subject is instructed to test her urine at home until an LH surge is detected.

When the subject ovulates and is available for a visit she will come to the Rockefeller University Hospital within one day of detecting an LH surge for the first of four Test Sessions.

The four Test Sessions are identical with the exception that the subject is exposed to a different odor stimulus.

We will be measuring:

  1. skin temperature
  2. sweating, as measured by skin conductance
  3. salivary cortisol levels.
  4. mood
Time Perspective: Prospective
Not Provided
Retention:   Samples With DNA
Non-Probability Sample
Healthy adult women between 18-35 years of age.
Not Provided
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*   Includes publications given by the data provider as well as publications identified by Identifier (NCT Number) in Medline.
July 2010
July 2010   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • Healthy adult women between 18-35 years of age.
  • Only subjects whose threshold to either vanillin or isovaleric acid is in the 90th percentile of the population tested in LVO-0539-0507 and who do not report any clinical conditions that may disturb their sense of smell will be enrolled in the study.

Exclusion Criteria:

  • Use of oral contraceptives over the last 3 months
  • Pregnancy
  • Allergies to odors or fragrances
  • History of nasal illness
  • Irregular menstrual periods
  • History of medical conditions that reduced or abolished sense of smell, such as: head injury, cancer therapy, radiation to the head and neck, or alcoholism.
Sexes Eligible for Study: Female
18 Years to 35 Years   (Adult)
Contact information is only displayed when the study is recruiting subjects
United States
Not Provided
Not Provided
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Rockefeller University
Rockefeller University
Not Provided
Principal Investigator: Leslie Vosshall, Ph.D. The Rockefeller University
Rockefeller University
February 2012

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP