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Differential Metabolic Effects of Statins

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT00546559
Recruitment Status : Completed
First Posted : October 19, 2007
Last Update Posted : August 29, 2008
Sponsor:
Information provided by:

October 18, 2007
October 19, 2007
August 29, 2008
January 2004
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Simvastatin and pravastatin may have differential metabolic effects in hypercholesterolemic patients.
Same as current
Complete list of historical versions of study NCT00546559 on ClinicalTrials.gov Archive Site
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Differential Metabolic Effects of Statins
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The investigators hypothesized simvastatin and pravastatin may have differential metabolic effects in hypercholesterolemic patients.
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Observational
Observational Model: Case Control
Time Perspective: Prospective
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Hypercholesterolemia
Drug: statins (simvastatin, pravastatin)
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Yada T, Nakata M, Shiraishi T, Kakei M. Inhibition by simvastatin, but not pravastatin, of glucose-induced cytosolic Ca2+ signalling and insulin secretion due to blockade of L-type Ca2+ channels in rat islet beta-cells. Br J Pharmacol. 1999 Mar;126(5):1205-13.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
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March 2008
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Inclusion Criteria:

  • Low-density lipoprotein cholesterol levels > 130

Exclusion Criteria:

  • Overt liver disease,
  • Chronic renal failure
  • Hypothyroidism
  • Myopathy
  • Uncontrolled diabetes
  • Severe hypertension
Sexes Eligible for Study: All
25 Years to 75 Years   (Adult, Senior)
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Contact information is only displayed when the study is recruiting subjects
Korea, Republic of
 
 
NCT00546559
GMC-200406
Yes
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Gachon University Gil Medical Center
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Principal Investigator: Kwang K Koh, MD,PhD Gachon University Gil Medical Center
Gachon University Gil Medical Center
August 2008