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Optical Sensor for Photodynamic Detection of Oral Pathology

This study is currently recruiting participants. (see Contacts and Locations)
Verified February 2016 by University of California, Irvine
Sponsor:
Collaborator:
Beckman Laser Institute University of California Irvine
Information provided by (Responsible Party):
Beckman Laser Institute and Medical Center, University of California, Irvine
ClinicalTrials.gov Identifier:
NCT00540774
First received: October 4, 2007
Last updated: February 5, 2016
Last verified: February 2016

October 4, 2007
February 5, 2016
April 2003
July 2018   (final data collection date for primary outcome measure)
Healthy oral tissue [ Time Frame: up to 12 months ] [ Designated as safety issue: No ]
Develop a non-invasive tool for the detection, diagnosis and screening of oral pathology and understanding of processes involved in oral pathology
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Complete list of historical versions of study NCT00540774 on ClinicalTrials.gov Archive Site
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Optical Sensor for Photodynamic Detection of Oral Pathology
Optical Sensor for Photodynamic Detection of Oral Pathology
Overall objective of this work is to identify changes in the optical properties of tissues, and to compare these with conventional semi-quantitative histo-pathological assessment to (1) gain a better understanding of processes involved in oral pathology and (2) develop a non-invasive tool for the detection, diagnosis and screening of oral pathology.

The researcher can use Optical Sensor for imaging the oral tissues. The Imaging system is a non-invasive imaging device and can measure the change in oral tissues. This imaging device is a non-invasive, non-significant risk use for optical tissue biopsy and can reduce procedural complication from clinical standard surgical tissue biopsy procedure.

The imaging devices are;

  1. Coherence and Doppler Tomography (OCT)
  2. Laser Speckle Imaging (LSI)
  3. Photon Migration Spectroscopy (PMS)

The researcher use toothpaste call Livionex Colgate Product to evaluate oral tissues changes and use the imaging devices to measure the changes of oral tissues.

Observational
Observational Model: Case-Only
Time Perspective: Prospective
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Non-Probability Sample
Study population will be recruited from University of Californis Irvine and Orange Country Dentists.
Mouth Diseases
Device: detection of oral pathology
detection of oral pathology
Oral tissue
detection of oral pathology
Intervention: Device: detection of oral pathology
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
150
July 2018
July 2018   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Male or Female age 18 years and older
  • Have oral lesion or not have oral lesion
  • Have condition of dry mouth
  • Have condition of Gum disease
  • Non-smoker

Exclusion Criteria:

  • Age less than 18 years old
  • Advanced gum disease, diseases of oral tissue
  • Untreated cavities
  • Pregnant or breastfeeding
  • Immune compromised individuals
Both
18 Years to 75 Years   (Adult, Senior)
Yes
Contact: Montana Compton, R.N 949-824-9265 mocomton@uci.edu
United States
 
NCT00540774
NIH/LAMMP-2002-2805, CRO-2009-XER-01-DM
No
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Beckman Laser Institute and Medical Center, University of California, Irvine
University of California, Irvine
Beckman Laser Institute University of California Irvine
Principal Investigator: Petra Wilder-Smith, DDS,PhD Beckman Laser Institute, University of Calfornia Irvine
University of California, Irvine
February 2016

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP