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Simvatstatin Used to Treat Pulmonary Hypertension

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified September 2007 by Capital Medical University.
Recruitment status was:  Not yet recruiting
Sponsor:
ClinicalTrials.gov Identifier:
NCT00538044
First Posted: October 2, 2007
Last Update Posted: October 2, 2007
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Capital Medical University
October 1, 2007
October 2, 2007
October 2, 2007
January 2009
Not Provided
  • the simvastatin can alleviate pulmonary hypertension
  • pulmonary pressure
Same as current
No Changes Posted
simvastatin can highten the perioperative and long term survaval rate and the living quality
Same as current
Not Provided
Not Provided
 
Simvatstatin Used to Treat Pulmonary Hypertension
the Clinical Research Using Simvastatin as a Medication to Treat Advanced Secondary Pulmonary Hypertension
we try to use simvastatin in the treatment of advanced pulmoary hypertension secondary to congenital heart disease or chronic pulmonary embolism before and after the operation.
advanced pulmonary hypertension is refractory to the medication in use nowaday, especially pulmonary hypertension secondary to congenital heart disease or chronic pulmonary embolism.It is revealed that statins may intefere the pathogenisis of the pulmonary hypertension in many key poing, such as improving apotosis or inhiting the proliferation of pulmonary vascular smooth muscle cell. so we try to use simvastatin in the treatment of advanced pulmoary hypertension secondary to congenital heart disease or chronic pulmonary embolism before and after the operation.
Interventional
Phase 1
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Investigator)
Primary Purpose: Treatment
Hypertension, Pulmonary
Drug: simvastatin
medication with simvastation on the dosage of 40mg per day before the operation and all the time after the operation
  • Experimental: 1simvastatin group
    before the operation, the patient start the simvastatin medication on the dosage of 40mg per day
    Intervention: Drug: simvastatin
  • No Intervention: 2contral group
    just do routin operation with no use of simvastatin, other medication is exact the same as the simvastatin group
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Unknown status
Not Provided
January 2012
Not Provided

Inclusion Criteria:

  • pasp>50mmHg

Exclusion Criteria:

  • pasp<50mmhg
Sexes Eligible for Study: All
12 Years to 70 Years   (Child, Adult, Senior)
No
Contact information is only displayed when the study is recruiting subjects
China
 
 
NCT00538044
Gan1
Anzhen1
Yes
Not Provided
Not Provided
Not Provided
Capital Medical University
Not Provided
Study Chair: Huili Gan, MD,Ph.D. Beijing Anzehn Hospital
Capital Medical University
September 2007

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP