Working…
COVID-19 is an emerging, rapidly evolving situation.
Get the latest public health information from CDC: https://www.coronavirus.gov.

Get the latest research information from NIH: https://www.nih.gov/coronavirus.
ClinicalTrials.gov
ClinicalTrials.gov Menu

Language in Primary Progressive Aphasia

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT00537004
Recruitment Status : Recruiting
First Posted : September 28, 2007
Last Update Posted : September 20, 2019
Sponsor:
Collaborator:
National Institute on Deafness and Other Communication Disorders (NIDCD)
Information provided by (Responsible Party):
Marsel Mesulam, Northwestern University

Tracking Information
First Submitted Date September 26, 2007
First Posted Date September 28, 2007
Last Update Posted Date September 20, 2019
Study Start Date May 2007
Estimated Primary Completion Date April 2022   (Final data collection date for primary outcome measure)
Current Primary Outcome Measures
 (submitted: April 2, 2013)
Neuropsychological variables [ Time Frame: Immediately after testing and at two years post-testing ]
Original Primary Outcome Measures Not Provided
Change History
Current Secondary Outcome Measures Not Provided
Original Secondary Outcome Measures Not Provided
Current Other Pre-specified Outcome Measures Not Provided
Original Other Pre-specified Outcome Measures Not Provided
 
Descriptive Information
Brief Title Language in Primary Progressive Aphasia
Official Title Language in Primary Progressive Aphasia
Brief Summary The purpose of this study is to further define the neurological and linguistic deterioration in primary progressive aphasia.
Detailed Description

The Language in Primary Progressive Aphasia (PPA) aims to understand the behavioral, anatomical and physiological changes in people with PPA throughout the course of the illness. The researchers in this study want to increase awareness of PPA, educate others about this unique disorder, and to encourage more research to eventually develop therapies.

During the three-day research program, participants will be asked to undergo neuropsychological testing (paper and pencil tests that evaluate cognition), advanced imaging (MRI and PET), eyetracking experiments, and other computer and language testing batteries. Participants may be asked to return every two years to complete the same measures.

For participants not living near Chicago, IL, flights and accommodations (for both the person with PPA and their companion) will be covered by the study.

Study Type Observational
Study Design Observational Model: Cohort
Time Perspective: Prospective
Target Follow-Up Duration Not Provided
Biospecimen Not Provided
Sampling Method Non-Probability Sample
Study Population Participants with PPA will be recruited from the Northwestern University Alzheimer's Disease Center Core registry, the Northwestern University Neurobehavior and Memory Clinic, and from those who contact the center that are interested in PPA research.
Condition Primary Progressive Aphasia
Intervention Not Provided
Study Groups/Cohorts
  • PPA (Primary Progressive Aphasia)
    Individuals with primary progressive aphasia
  • Control
    Individuals with no diagnosis of any type of dementia
Publications *

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruitment Information
Recruitment Status Recruiting
Estimated Enrollment
 (submitted: April 2, 2013)
300
Original Estimated Enrollment
 (submitted: September 26, 2007)
120
Estimated Study Completion Date April 2023
Estimated Primary Completion Date April 2022   (Final data collection date for primary outcome measure)
Eligibility Criteria

Inclusion Criteria:

  • Diagnosis of primary progressive aphasia
  • Right-handed
  • English speaker
  • Visual acuity of 20/30 corrected
  • Adequate hearing to follow conversation
  • Safe for an MRI scan

Exclusion Criteria:

  • Left-handedness
  • Claustrophobia
  • Presence of significant medical illness that initially or in the future could interfere with continued participation in the study
Sex/Gender
Sexes Eligible for Study: All
Ages Child, Adult, Older Adult
Accepts Healthy Volunteers No
Contacts
Contact: Christina Coventry, MS, RN 312-908-9681 christina.coventry@northwestern.edu
Listed Location Countries United States
Removed Location Countries  
 
Administrative Information
NCT Number NCT00537004
Other Study ID Numbers IA0125
R01DC008552 ( U.S. NIH Grant/Contract )
Has Data Monitoring Committee No
U.S. FDA-regulated Product Not Provided
IPD Sharing Statement Not Provided
Responsible Party Marsel Mesulam, Northwestern University
Study Sponsor Northwestern University
Collaborators National Institute on Deafness and Other Communication Disorders (NIDCD)
Investigators
Principal Investigator: Marsel Mesulam, MD Northwestern University Feinberg School of Medicine
PRS Account Northwestern University
Verification Date September 2019