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Trial record 12 of 79 for:    "Bronchiolitis obliterans"

Correlation of Lung Biopsy, BAL, and High Resolution CT Scan in Lung Transplantation

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ClinicalTrials.gov Identifier: NCT00528853
Recruitment Status : Completed
First Posted : September 12, 2007
Last Update Posted : August 19, 2016
Sponsor:
Information provided by (Responsible Party):
University of Chicago

September 10, 2007
September 12, 2007
August 19, 2016
August 2007
December 2009   (Final data collection date for primary outcome measure)
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Complete list of historical versions of study NCT00528853 on ClinicalTrials.gov Archive Site
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Correlation of Lung Biopsy, BAL, and High Resolution CT Scan in Lung Transplantation
Correlation of Lung Biopsy, BAL, and High Resolution CT Scan in Lung Transplantation. Can We Help Diagnose Acute Rejection and Better Predict Bronchiolitis Obliterans?

A major source of graft failure and dysfunction in lung transplantation is known to be bronchiolitis obliterans (BO)and its clinical correlate called bronchiolitis obliterans syndrome(BOS). In fact, BOS is the leading cause of death in lung recipients beyond one year post transplant. Currently, our ability to assess lung injury after transplant is less than ideal.

The purpose of this study is to use new computerized tomography(CT) technology, specifically , 64 bit acquisition, to detect and predict the onset of lung injuries, with the hope of finding better therapies that currently exist.

Total enrollment : 10

Lung transplant patients will undergo CT Scans before scheduled bronchoscopies which are routinely performed at 1, 3, 6, 9, and 12 months post transplant. Imaging will be done with the newest generation scanner, with intent to analyze all pertinent areas of the lung for pathology, but especially the bronchial anastomoses, the lung parenchyma with focus on gas exchanging lobules of the lung, and any suspected abnormalities from physical exam, laboratory tests, or prior chest xray.

CT imaging will precede bronchoscopy and biopsy so that CT interpretation will be unencumbered by changes due to the bronchoscopic procedure.

Observational
Observational Model: Case-Only
Time Perspective: Prospective
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Non-Probability Sample
Lung transplant patients meeting inclusion criteria will be recruited from the lung transplant clinic.
Bronchiolitis Obliterans Syndrome
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
10
Same as current
December 2009
December 2009   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • Lung transplant patients who are at least 18 years of age.
  • All patients must be able to give written informed consent.

Exclusion Criteria:

  • Lung transplant patients who are unable to undergo a CT Scan.
  • Lung transplant patients who are unable to give informed consent.
Sexes Eligible for Study: All
18 Years to 65 Years   (Adult, Older Adult)
No
Contact information is only displayed when the study is recruiting subjects
United States
 
 
NCT00528853
15660A
No
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University of Chicago
University of Chicago
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Principal Investigator: Edward Garrity, MD University of Chicago
University of Chicago
August 2016