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Body Composition, Bone Mineral Density, Insulin Sensitivity and Echocardiographic Measurements in Klinefelter Syndrome

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ClinicalTrials.gov Identifier: NCT00523835
Recruitment Status : Completed
First Posted : September 3, 2007
Last Update Posted : September 3, 2007
Sponsor:
Information provided by:
University of Aarhus

August 31, 2007
September 3, 2007
September 3, 2007
April 2002
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No Changes Posted
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Body Composition, Bone Mineral Density, Insulin Sensitivity and Echocardiographic Measurements in Klinefelter Syndrome
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Klinefelter syndrome (KS) is the most common sex-chromosome disorder with a prevalence of one in 660 men and is a frequent cause of hypogonadism and infertility. It is caused by the presence of extra X-chromosomes, the most common karyotype being 47,XXY. The phenotype is variable, but the most constant finding is small hyalinized testes, hypergonadotrophic hypogonadism, infertility, eunuchoid body proportion, increased height and learning disabilities. Klinefelter syndrome has been associated with increased prevalence of diabetes, osteoporosis and cardiovascular diseases but the pathogenesis is unknown. Accordingly the aim of the study was to investigate measures of body composition, insulin sensitivity, bone mineral density, echocardiography, as well as biochemical markers of endocrine, metabolic and bone function in KS and an age-matched control group.
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Observational
Observational Model: Natural History
Time Perspective: Cross-Sectional
Time Perspective: Prospective
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  • Klinefelter Syndrome
  • Diabetes
  • Osteoporosis
  • Metabolic Syndrome
  • Cardiovascular Disease
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  • Case: KS
    Patients with Klinefelter syndrome verified by chromosome analysis
  • Control: Normal
    Normal men Age matched to KS patients

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
140
Same as current
November 2004
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Inclusion Criteria:

  • age above 18 years
  • verified KS karyotype (KS patients)

Exclusion Criteria:

  • untreated hypothyroidism or hyperthyroidism
  • present or past malignant diseases
  • clinical liver disease
  • treatment with drugs knowing to interfere with glucose homeostasis, fat metabolism or bone modulation (e.g. glucocorticoids)
Sexes Eligible for Study: Male
18 Years and older   (Adult, Older Adult)
Yes
Contact information is only displayed when the study is recruiting subjects
Denmark
 
 
NCT00523835
20010155
No
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University of Aarhus
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Study Chair: Jens S. Christiansen, Professor Medical department M, Endocrinology and Diabetes, and Medical Research Laboratories, Clinical Institute, Aarhus University Hospital, Denmark
Principal Investigator: Anders B Bojesen, MD, PhD Medical department M, Endocrinology and Diabetes, and Medical Research Laboratories, Clinical Institute, Aarhus University Hospital, Denmark
Study Director: Claus H Gravholt, MD, DMsc, PhD Medical department M, Endocrinology and Diabetes, and Medical Research Laboratories, Clinical Institute, Aarhus University Hospital, Denmark
University of Aarhus
August 2007