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Effects of Exercise Modality on Abdominal Obesity and Health Risk Factors in Older Men and Women

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00520858
Recruitment Status : Completed
First Posted : August 27, 2007
Last Update Posted : April 22, 2008
Canadian Institutes of Health Research (CIHR)
Information provided by:
Queen's University

August 24, 2007
August 27, 2007
April 22, 2008
September 2003
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Abdominal obesity [ Time Frame: 6 months ]
Same as current
Complete list of historical versions of study NCT00520858 on Archive Site
Insulin Resistance [ Time Frame: 6 Months ]
Same as current
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Effects of Exercise Modality on Abdominal Obesity and Health Risk Factors in Older Men and Women
Effects of Exercise Modality on Abdominal Obesity and Health Risk Factors in Older Men and Women
The prevalence of abdominal obesity in the elderly is increasing at alarming rates and thus, requires immediate attention. By comparison to younger adults, obesity reduction in the elderly presents a unique challenge and requires an innovative approach. We propose a novel approach to investigate the effects of different exercise types as independent treatment strategies for the reduction of obesity and related health risk factors in older men and women. We propose that exercise without caloric restriction will be associated with modest weight loss (3-5%), that in turn will be associated with significant reduction in abdominal obesity, insulin resistance, and a corresponding increase in skeletal muscle mass and function. We will determine the separate effects of resistance and aerobic exercise on these primary outcome variables, and, whether a treatment strategy that combines the two is optimal.
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Intervention Model: Parallel Assignment
Masking: Single (Investigator)
Primary Purpose: Treatment
Abdominal Obesity
  • Other: Resistance Exercise (RE)
  • Other: Aerobic Exercise (AE)
  • Other: Resistance and Aerobic Exercise (RAE)
  • No Intervention: C
  • Active Comparator: RE
    Resistance Exercise
    Intervention: Other: Resistance Exercise (RE)
  • Active Comparator: AE
    Aerobic Exercise
    Intervention: Other: Aerobic Exercise (AE)
  • Active Comparator: RAE
    Resistance and Aerobic
    Intervention: Other: Resistance and Aerobic Exercise (RAE)
Davidson LE, Hudson R, Kilpatrick K, Kuk JL, McMillan K, Janiszewski PM, Lee S, Lam M, Ross R. Effects of exercise modality on insulin resistance and functional limitation in older adults: a randomized controlled trial. Arch Intern Med. 2009 Jan 26;169(2):122-31. doi: 10.1001/archinternmed.2008.558.

*   Includes publications given by the data provider as well as publications identified by Identifier (NCT Number) in Medline.
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Inclusion Criteria:

  • Men and women between 65 and 80 years of age.
  • Men and women are self-sufficient, sedentary, abdominally obese (BMI between 27 and 34.9 kg/m2; waist circumference greater than 88 cm in women and 102 cm in men), weight stable (± 2 kg) for 6 months prior to the beginning of the study, be non-smokers, and not diabetic.
  • We will study elderly women who are not taking hormone replacement therapy to create a homogeneous population in whom the effect of exercise on the principal outcome variables can be evaluated with minimal confounding.

Exclusion Criteria:

  • Smokers and diabetics.
  • Women taking hormone replacement therapy.
Sexes Eligible for Study: All
65 Years to 80 Years   (Adult, Senior)
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Contact information is only displayed when the study is recruiting subjects
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Queen's University
Canadian Institutes of Health Research (CIHR)
Principal Investigator: Robert Ross Queen's University
Queen's University
April 2008

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP