Neuroimaging Studies of Depression in Parkinson's Disease

This study has been completed.
Information provided by (Responsible Party):
Lee Blonder, University of Kentucky Identifier:
First received: August 16, 2007
Last updated: May 16, 2013
Last verified: April 2013

August 16, 2007
May 16, 2013
July 2006
December 2011   (final data collection date for primary outcome measure)
Not Provided
Not Provided
Complete list of historical versions of study NCT00518258 on Archive Site
Not Provided
Not Provided
Not Provided
Not Provided
Neuroimaging Studies of Depression in Parkinson's Disease
Neuroimaging Studies of Depression in Parkinson's Disease

The purpose of this study is to investigate similarities and differences in the neural pathways of depressed Parkinson's patients, non-depressed Parkinson's patients, and healthy controls using magnetic resonance imaging (MRI) of the brain and neuropsychological assessment.

Depression is a common and potentially serious complication of Parkinson's disease (PD). Studies show that approximately 40 percent of PD patients are depressed. There is evidence that these patients have deficits in neuropsychological function relative to non-depressed PD patients. Despite the widespread toll on emotional health posed by PD, few studies have undertaken a comprehensive examination of the neural underpinnings of Parkinsonian depression. In this project, we will compare depressed versus non-depressed Parkinson patients to a sample of demographically-matched healthy controls using neuropsychological assessment and magnetic resonance imaging (MRI). To investigate possible effects of anti-Parkinsonian medication on mood, cognitive function, and neural response, PD patients will be tested both off and on Parkinsonian medications.

Observational Model: Case Control
Time Perspective: Prospective
Not Provided
Not Provided
Non-Probability Sample

Neurology clinics, community sample

Parkinson's Disease
Not Provided
  • 1
    Patient Group
  • 2
    Control Group
Not Provided

*   Includes publications given by the data provider as well as publications identified by Identifier (NCT Number) in Medline.
December 2011
December 2011   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • right-handed
  • willing/able to undergo magnetic resonance imaging (MRI)

Exclusion Criteria:

  • history of neurological condition other than Parkinson's disease
  • history of psychiatric condition other than depression
  • history of substance abuse/dependence
40 Years to 85 Years
Contact information is only displayed when the study is recruiting subjects
United States
Lee Blonder, University of Kentucky
Lee Blonder
  • National Institute of Mental Health (NIMH)
  • National Institute of Neurological Disorders and Stroke (NINDS)
Principal Investigator: Lee X. Blonder, PhD University of Kentucky
University of Kentucky
April 2013

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP