Effects of Acetazolamide and CO2 Inhalation on Exercise-induced Periodic Breathing in Heart Failure

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Piergiuseppe Agostoni, Centro Cardiologico Monzino
ClinicalTrials.gov Identifier:
NCT00517426
First received: August 16, 2007
Last updated: January 27, 2016
Last verified: January 2016

August 16, 2007
January 27, 2016
July 2007
July 2011   (final data collection date for primary outcome measure)
Suppression of periodic breathing [ Time Frame: two days ] [ Designated as safety issue: No ]
Suppression of periodic breathing [ Time Frame: two days ]
Complete list of historical versions of study NCT00517426 on ClinicalTrials.gov Archive Site
suppression of sleeping apnea [ Time Frame: two days ] [ Designated as safety issue: No ]
suppression of sleeping apnea [ Time Frame: two days ]
Not Provided
Not Provided
 
Effects of Acetazolamide and CO2 Inhalation on Exercise-induced Periodic Breathing in Heart Failure
Not Provided

To evaluate the effects of CO2 inhalation and acetazolamide treatment on exercise-induced periodic breathing in patients with chronic stable heart failure.

Patients will be given CO2 (2%) during a constant workload exercise. Patients will be also evaluated by maximal cardiopulmonary exercise test without and with acetazolamide acute and chronic treatment.

Not Provided
Interventional
Phase 4
Endpoint Classification: Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Chronic Heart Failure
Drug: acetazolamide
i.v. 500 mg of acetazolamide for the acute study and 500 mg of acetazolamide p.o. t.i.d. for two days
Other Name: Diamox
Experimental: Active Acetazolamide
Intervention: Drug: acetazolamide
Agostoni P, Bussotti M, Cattadori G, Margutti E, Contini M, Muratori M, Marenzi G, Fiorentini C. Gas diffusion and alveolar-capillary unit in chronic heart failure. Eur Heart J. 2006 Nov;27(21):2538-43. Epub 2006 Oct 6.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
20
August 2012
July 2011   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • chronic heart failure in stable clinical condition
  • exercise-induced periodic breathing

Exclusion Criteria:

  • comorbidities
  • NYHA class IV
Both
18 Years to 80 Years   (Adult, Senior)
No
Contact information is only displayed when the study is recruiting subjects
Italy
 
NCT00517426
R77-CCM S79/407
No
Not Provided
Not Provided
Piergiuseppe Agostoni, Centro Cardiologico Monzino
Centro Cardiologico Monzino
Not Provided
Principal Investigator: Piergiuseppe Agostoni, MD, PhD Centro Cardiologico Monzino
Centro Cardiologico Monzino
January 2016

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP