A Comparison of Hydrogel Dressings and Ocular Lubricants in the Prevention on Corneal Damage in the Critically Ill

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00513734
Recruitment Status : Completed
First Posted : August 9, 2007
Last Update Posted : August 9, 2007
Information provided by:
Barts & The London NHS Trust

August 8, 2007
August 9, 2007
August 9, 2007
September 2004
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Development of clinically significant corneal exposure [ Time Frame: throughout length of admission to ITU ]
Same as current
No Changes Posted
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A Comparison of Hydrogel Dressings and Ocular Lubricants in the Prevention on Corneal Damage in the Critically Ill
Randomised Trial Comparing the Efficacy of Ocular Lubricant (Lacrilube) and Polyacrylamide Hydrogel Dressing (Geliperm) for the Prevention of Exposure Keratopathy in the Critically Ill
Corneal damage in critically ill patients is common. There are currently two popular methods of treatment in the UK; hydrogel dressings and lubricating ointment. We propose to randomise patients to have a different treatment for each eye and see which one is more effective.
Microbial keratitis, particularly pseudomonas-related, has been widely reported amongst Intensive therapy unit (ITU) patients and the need for effective eye care in ITU has been recognised for some time. We compare two popular methods of eye care; a hydrogel dressing and lacrilube ointment. Each recruited patient had each eye randomised to different treatments. Daily ophthalmology ward rounds were undertaken to identify any corneal exposure keratopathy. Patients were removed from the trial if one eye developed significant exposure needing treatment.
Not Applicable
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single
Primary Purpose: Prevention
  • Other: Hydrogel dressing
    3x3cm hydrogel dressing over closed eye
  • Other: Lacrilube ointment
    lubricant put into eye (inferior formix)
  • Active Comparator: 1
    Geliperm Hydrogel Dressing
    Intervention: Other: Hydrogel dressing
  • Active Comparator: 2
    Lacrilube ointment
    Intervention: Other: Lacrilube ointment
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*   Includes publications given by the data provider as well as publications identified by Identifier (NCT Number) in Medline.
Same as current
February 2005
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Inclusion Criteria:

  • All patients admitted to Intensive care and expected to stay for more than 2 days

Exclusion Criteria:

  • Primary orbital injury
Sexes Eligible for Study: All
18 Years and older   (Adult, Senior)
Contact information is only displayed when the study is recruiting subjects
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Barts & The London NHS Trust
Not Provided
Study Director: Marie Healy, FRCA Lead Clinicain, Dept. of Intensive Care Medicine, Royal London Hospital, London E1 1BB
Barts & The London NHS Trust
August 2007

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP