AZD1152 in Patients With Advanced Solid Malignancies-Study 3

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00497679
Recruitment Status : Terminated (Study is now terminated due to technical difficulties with administration of study drug in this patient population with this schedule)
First Posted : July 9, 2007
Last Update Posted : May 14, 2009
Information provided by:

July 5, 2007
July 9, 2007
May 14, 2009
August 2006
Not Provided
Safety and Tolerability [ Time Frame: Assessed at each visit ]
Same as current
Complete list of historical versions of study NCT00497679 on Archive Site
  • Pharmacokinetics [ Time Frame: Assessed at predetermined timepoints after dose administration ]
  • Effect on biomarkers [ Time Frame: Assessed after treatment ]
  • Anti-tumor activity [ Time Frame: Assessed at the end of treatment ]
Same as current
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AZD1152 in Patients With Advanced Solid Malignancies-Study 3
A Phase I, Open-Label, Multi-Centre Study to Assess the Safety, Tolerability and Pharmacokinetics of AZD1152 Given as a Continuous 7-Day Intravenous Infusion in Patients With Advanced Solid Malignancies
The primary purpose of this protocol is to investigate the safety and tolerability of AZD1152 when given as a continuous 7-day infusion every week and every 2 weeks in patients with advanced solid malignancies.
Not Provided
Phase 1
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Solid Tumours
Drug: AZD1152
7-day continuous intravenous infusion
Not Provided
Not Provided

*   Includes publications given by the data provider as well as publications identified by Identifier (NCT Number) in Medline.
July 2007
Not Provided

Inclusion Criteria:

  • Histological or cytological confirmation of a solid, malignant tumour

Exclusion Criteria:

  • Participation in an investigational drug study within 21 days prior to entry or who have not recovered from the effects of an investigational study drug
  • Treatment with radiotherapy/chemotherapy with 4 weeks of first dose
  • Recent major surgery within 4 weeks prior to entry to the study
Sexes Eligible for Study: All
18 Years and older   (Adult, Senior)
Contact information is only displayed when the study is recruiting subjects
United Kingdom
EudraCT: 2005-004244-31
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Principal Investigator: David Kerr, MD University of Oxford
May 2009

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP