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Early Diagnosis, Pathogenesis and Progression of Open Angle Glaucoma

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ClinicalTrials.gov Identifier: NCT00494923
Recruitment Status : Recruiting
First Posted : July 2, 2007
Last Update Posted : December 12, 2013
Sponsor:
Collaborator:
German Research Foundation
Information provided by (Responsible Party):
University of Erlangen-Nürnberg Medical School

June 29, 2007
July 2, 2007
December 12, 2013
January 1999
December 2015   (Final data collection date for primary outcome measure)
Time to Disease Progression [ Time Frame: up to 20 years ]
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Complete list of historical versions of study NCT00494923 on ClinicalTrials.gov Archive Site
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Early Diagnosis, Pathogenesis and Progression of Open Angle Glaucoma
Glaucoma Including Pseudoexfoliation Syndrome (SFB 539)
The Erlangen Glaucoma Registry is a clinical registry for cross sectional and longitudinal observation of patients with open angle glaucoma (OAG) or glaucoma suspect, founded in 1991. The primary aim is the evaluation of diagnostic and prognostic validity of morphometrical, sensory and hemodynamical diagnostic procedures. No therapeutic studies are performed.
Purpose: Detection of onset and progression of structural and functional damage due to glaucoma. Determination of rate and amount of progressive change due to glaucoma. Characterisation of the relationship between structural and functional change over time. Evaluation of predictive factors for the development and progression of glaucoma.
Observational
Observational Model: Cohort
Time Perspective: Prospective
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Retention:   Samples With DNA
Description:
whole blood
Non-Probability Sample
primary care clinic
  • Primary Open Angle Glaucoma
  • Secondary Open Angle Glaucoma
  • Ocular Hypertension
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
2500
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December 2020
December 2015   (Final data collection date for primary outcome measure)

Participants:

  • Patients: Primary open angle glaucoma, secondary open angle glaucoma due to PEX or MDS, glaucoma suspects including ocular hypertension
  • Healthy volunteers (for cross sectional analysis only)

Inclusion Criteria:

  • Open anterior chamber angle
  • Best corrected visual acuity 0.7 or better
  • Age between 18 and 65 years

Exclusion Criteria:

  • Any eye disease other than glaucoma
  • Systemic diseases with potentially ocular involvement (e.g., diabetes mellitus)
  • Myopic or hyperopic refractive error exceeding 8.0 diopters
Sexes Eligible for Study: All
18 Years to 65 Years   (Adult, Older Adult)
Yes
Contact: Anselm G Juenemann, Prof. **49-9131-8533001 anselm.juenemann@uk-erlangen.de
Germany
 
 
NCT00494923
DFG-SFB539-R
No
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University of Erlangen-Nürnberg Medical School
University of Erlangen-Nürnberg Medical School
German Research Foundation
Study Chair: Anselm G Juenemann, Prof. University Erlangen-Nuremberg
University of Erlangen-Nürnberg Medical School
December 2013