Time Perception Deficits and Attention-Deficit/Hyperactivity Disorder
|ClinicalTrials.gov Identifier: NCT00491647|
Recruitment Status : Completed
First Posted : June 26, 2007
Last Update Posted : November 14, 2012
|First Submitted Date||June 23, 2007|
|First Posted Date||June 26, 2007|
|Last Update Posted Date||November 14, 2012|
|Start Date||May 2006|
|Primary Completion Date||Not Provided|
|Current Primary Outcome Measures||Not Provided|
|Original Primary Outcome Measures||Not Provided|
|Change History||Complete list of historical versions of study NCT00491647 on ClinicalTrials.gov Archive Site|
|Current Secondary Outcome Measures||Not Provided|
|Original Secondary Outcome Measures||Not Provided|
|Current Other Outcome Measures||Not Provided|
|Original Other Outcome Measures||Not Provided|
|Brief Title||Time Perception Deficits and Attention-Deficit/Hyperactivity Disorder|
|Official Title||Time Perception Deficits and Behaviors of Children and Adolescents With Attention-Deficit/Hyperactivity Disorder|
Background: Literature has documented that children with attention-deficit/ hyperactivity disorder (ADHD) have difficulties in time management by manifesting with difficulties making plans, organizing tasks and activities, and awaiting their turns. However, the studies regarding time perception have been few as compared to those of neuropsychological measures and there is no information about this topic in Chinese population. In view of this, we will conduct a study to investigate the clinical and treatment aspects of time perception among children and adolescent with ADHD.
Anticipated Results: We anticipated that the ADHD group will have poorer time perception, particularly in difficult tasks, and the impairment will be reduced after treatment with medication
BACKGROUND Children with attention-deficit/hyperactivity disorder (ADHD), a common, impairing neuropsychiatric disorder, are more likely to have difficulties planning and organizing. They cannot do things in an efficient way, cannot feel the limit of time schedule, and have difficulties awaiting their turns (Barkley, 1998). They often spend much longer time in homework, forget to accomplish routines or prescheduled work. Such behaviors often result in conflicts in the parent-child relationship.
In order to measure time perception, Barkley et al. (1997) developed two rating scales to evaluate children's sense of time and their ability of time management. They found an association between ADHD and poor time management. Barkley's (1998) comprehensive model suggested that time perception deficits in children with ADHD are due to deficits in behavioral inhibition and executive functions. Barkley et al's time reproduction tasks showed that children (1997), adolescents and young adults (2001) with ADHD had significantly more errors.
Recent studies focused on the associations of time reproduction with sustained attention, working memory, and behavioral inhibition. Kerns et al. (2001) reported a positive association between performance on a measure of attention (CPT) and a time reproduction task with a mixed result on the relationships between time reproduction and inhibitory control and working memory. McInerney and Kerns (2003) found the associations of time reproduction with working memory and behavioral inhibition, which lend support to the notion that time reproduction requires executive functions.
Smith et al. (2002) found that children with ADHD are more impaired in time discrimination threshold and less sensitive in fine time perception. This finding was later supported by Toplak et al (2003, 2005) using different modalities such as visual and auditory stimuli.
All the time perception tasks require the ability to allocate attention; however, different tasks involve other different mental abilities for estimation of duration of presentation of a target. Verbal estimation task is more related to the length of one's subject time unit, as synonymous inner clock speed. Time discrimination and time reproduction are related to the duration comparison. In addition to estimating the duration in the time discrimination task, subjects need to allocate their attention for a longer time and then to produce a target with the same duration by using some executive functions such as behavioral inhibition, sustain attention and working memory.
Few studies examined the efficacy of medication treatment of ADHD on time perception. Although Barkley et al., (1997) did not find effect of psychostimulants on the time reproduction, Baldwin et al. (2004) found that MPH significantly decrease time response variability, and decreased lever holds of extremely short durations. These findings suggest that administration of MPH resulted in more precise time performance without changing the mean duration of lever holds.
Although current empirical data from a few studies support that ADHD have time perception deficit and MPH may be effective in improving time reproduction, there is no information about time perception deficits in the Chinese population. In view of this, we will conduct a study to investigate the clinical and treatment aspects of time perception among children and adolescent with ADHD.
METHODS Participants We will recruit 100 patients with DSM-IV ADHD, aged 9 to 16 years, and 100 school controls. The 100 patients with ADHD will reassessed with time perception tasks 3 to 6 months later after treatment at outpatient department.
Time Discrimination Task Time discrimination task, modified from Smith et al. (2002) presents the green circle on the left first, followed by the red circle on the right. The subject is asked to press the key to indicate the circle with longer duration. The standard stimuli and comparison last for 1000ms, and 1350ms, respectively. The two circles are randomly presented. If the answer is correct, the comparison duration decreases in 15ms; if the answer is wrong, the comparison duration increases in 15ms. The task continued either until the subject had made six reversals, or until 20 trials, whichever occurs first.
Time Reproduction Task The time reproduction task is modified from Barkley et al. (1997). First, the green circle is present on the central for seconds with five durations: 2, 5, 10, 12, and 17seconds. Subject is asked to press key to create the same temporal duration as green circle. Two trials are given at each of these five durations with random presentation.
The raw time reproduction is converted into the absolute discrepancy score, which consists of the absolute value of magnitude of the discrepancy between the participant's time production and the interval presented to the subject to measure the extent of errors.
Conners' Continuous Performance Test (CPT) The CPT requires tabbing on the space key when any character other than X shown on the screen. There were six sets in total, with 20 characters within each set. The Inter-Stimulus Intervals (ISIs) are 1, 2, and 4 seconds, and different ISIs varied between sets. Each character maintains on the screen for 250 ms. Correct hits, omission errors, commission errors, and reaction times will be collected as indices of response selection and capacity/focus. The d' value known as a discriminate factor is one of the indices for sustained attention.
The Wechsler Intelligence Scale for Children - the 3rd edition short form WISC-III (Wechsler, 1991) is a well established scale designed to assess the Full-Scale IQ (FSIQ) of children under age of 16. It includes 13 subtests to test children's cognitive ability of different dimensions. Test result is represented by Verbal IQ, Performance IQ, and Full-Scale IQ. The present research conducted a quad combination of WISC short form including subtests of Symbol Search, Arithmetic, Block Design, and Verbal. Previous research suggested the mentioned combination have good reliability (rxx = .91) and validity (rxx = .90) (Silverstein, 1982), and is preferred while conducting research to estimate FSIQ.
Procedure We will obtain written informed consent of all subjects from both children and their parents. The day prior to the date of receiving neuropsychological tasks, children will be asked to halt medication (if they are not drug-naïve patients) in order to obtain their test results as baseline data to make comparison with their performance after treatment with medication for 3 months or one year.
The testing procedure is as follows: (1) In addition to clinical diagnosis, subjects' mothers will receive K-SADS-E interview to make psychiatric diagnosis. (2) All subjects (ADHD group and normal controls) will be assessed IQ and a series of time perception tasks. Their parents will complete the SNAP-IV and CPRS-R:S and teachers will complete the CTRS-R:S. (3) After receiving medication for ADHD for 3 months and for one year, children will be reassessed by time perception tasks and CPT. Their parents and teachers will be asked to complete the same rating scales.
We anticipated that the ADHD group will perform poorer in time estimation, time discrimination, and time reproduction, particularly in difficult tasks, and the impairment will be reduced after treatment with medication.
|Study Design||Observational Model: Case Control|
|Target Follow-Up Duration||Not Provided|
|Sampling Method||Non-Probability Sample|
|Study Population||Children with and without ADHD|
|Study Groups/Cohorts||Not Provided|
|Publications *||Hwang SL, Gau SS, Hsu WY, Wu YY. Deficits in interval timing measured by the dual-task paradigm among children and adolescents with attention-deficit/hyperactivity disorder. J Child Psychol Psychiatry. 2010 Mar;51(3):223-32. doi: 10.1111/j.1469-7610.2009.02163.x. Epub 2009 Sep 15.|
* Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
|Completion Date||June 2007|
|Primary Completion Date||Not Provided|
|Ages||9 Years to 16 Years (Child)|
|Accepts Healthy Volunteers||No|
|Contacts||Contact information is only displayed when the study is recruiting subjects|
|Listed Location Countries||Taiwan|
|Removed Location Countries|
|Other Study ID Numbers||9561703011|
|Has Data Monitoring Committee||Yes|
|U.S. FDA-regulated Product||Not Provided|
|IPD Sharing Statement||Not Provided|
|Responsible Party||National Taiwan University Hospital|
|Study Sponsor||National Taiwan University Hospital|
|PRS Account||National Taiwan University Hospital|
|Verification Date||September 2008|