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The Role of Physical Activity in the Treatment of Children With Type 1 Diabetes. (4301)

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ClinicalTrials.gov Identifier: NCT00491465
Recruitment Status : Unknown
Verified June 2007 by Rabin Medical Center.
Recruitment status was:  Not yet recruiting
First Posted : June 26, 2007
Last Update Posted : June 26, 2007
Sponsor:
Information provided by:
Rabin Medical Center

June 25, 2007
June 26, 2007
June 26, 2007
July 2007
Not Provided
  • HbA1C [ Time Frame: 0,3 monthes ]
  • fructosamine [ Time Frame: 0,3 monthes ]
Same as current
No Changes Posted
  • Body composition & BMR [ Time Frame: 0,3 monthes ]
  • Self esteem & QOL questionnaires [ Time Frame: o, 3 monthes ]
  • 3 days CGMS & SBGM profile [ Time Frame: 0,3 monthes ]
Same as current
Not Provided
Not Provided
 
The Role of Physical Activity in the Treatment of Children With Type 1 Diabetes.
Randomized,Controlled,Open,Cross-Over Intervention Study for Evaluating the Role of Physical Activity in the Treatment of Children With Type 1 Diabetes.
Randomized, controlled, open, comparative intervention study in two groups, each consisting of 25 children with type 1 diabetes that will undergo twelve weeks of exercise program (intensive arm) and twelve weeks of regular activity (non intensive arm) separated by four week of washout period. The study will be conducted in a crossover manner: one group starting with the intensive arm followed by the non intensive arm and vice versa. Blood glucose, HbA1C, Fructosamine, 3 days continuous glucose monitoring system (CGMS), total daily insulin dose, fasting lipid profile, body impedance and BMR will be measured. Self esteem and quality of life questionnaires will be filled.

Randomized, controlled, open, comparative, cross-over, intervention study in 50 children with type 1 diabetes.

objectives:

Primary objective To evaluate the efficacy and safety of physical activity for metabolic control in children with type I diabetes.

Secondary objectives

  1. To characterize the severity and pattern of occurrence of hypo and hyperglycemic episodes during and after exercise program in type I diabetic children.
  2. To evaluate changes in insulin sensitivity during and after periods of exercise in type I diabetic children.
  3. To evaluate the short term effect of exercise on BMI and body composition in type I diabetic children.
  4. To evaluate the short term effect of exercise on lipid profile in type I diabetic children.
  5. To evaluate differences in self esteem and quality of life between exercising and non exercising type I diabetic children.

Randomization:

Children will be randomly allocated into two groups of 25.The study will be conducted in a crossover manner:one group starting with the intensive arm followed by the non intensive arm and vice versa.

methods:

  1. The study will have an intensive arm and a non intensive arm, each lasting 12 weeks.
  2. Children fulfilling the inclusion and exclusion criteria will be randomly assigned to two groups. Each group will include 25 patients.
  3. Participants will fill questionnaires regarding physical activity.
  4. The first group will start with the intensive arm, followed by one month washout, and then the non intensive arm.
  5. The second group will start the study with the non intensive arm, followed by one month washout and then the intensive arm .
  6. The intensive arm will consist of an exercise program which will include high intensity progressive exercise (75% maximum age adjusted heart rate HRmax) 3 days a week for 90 minutes. The 90 min exercise will be a combination of aerobic exercise 45min. and resistance exercise 45 min.
  7. The exercise program will be planned and carried out by professional sports instructors.
  8. During the non intensive arm the participants will resume regular daily activity. They will keep records of their weekly physical activity and will get a weekly phone call from the treating doctor, addressing specifically physical activity performed during the past week and glucose levels before and after exercise.
  9. The following parameters will be measured for both groups at the beginning and the end of the intensive and non intensive arm and once again 12 weeks afterwards : Weight, height, pulse, blood pressure, waist circumference, skin folds, HbA1C , fructosamine ,3 days CGMS +3 day SBGM profile (will be measured to 40% of participants chosen randomly) ,total daily insulin dose ,blood sample for fasting lipid profile ,Body impedance and BMR , self esteem and quality of life questionnaires .
  10. Study participants will be required to measure blood glucose by glucometer at least 4 times a day and to record hypo and hyperglycemic events and their severity.

15.Both children and investigators will be blinded to CGMS results. 16.During the 3 day CGMS recording, the children's parents will be asked to monitor SBGM once during the night (in the intensive arm, following the exercise day).

Interventional
Not Applicable
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)
Primary Purpose: Supportive Care
Type 1 Diabetes
  • Behavioral: Intensive Physical activity
  • Behavioral: Control- regular physical activity
Not Provided
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Unknown status
2007
Same as current
July 2009
Not Provided

Inclusion Criteria:

  1. Type I diabetic children
  2. Tanner stage II-IV
  3. Patients of the Schneider's national institute of childhood diabetes. Duration of diabetes
  4. more than one year.
  5. HbA1C between 8 and 12 at time 0.
  6. Mandatory 4 daily self blood glucose measurements and daily recording of adverse events.
  7. A signed informed consent of the parents and child.

Exclusion Criteria:

  1. Additional chronic significant disease such as cardiac, liver, renal disease .
  2. Children who exercise regularly more than 180 min per week.
  3. Cardiac symptoms: history of chest pain , syncope , palpitations or dyspnea during exercise.
  4. Eating disorders.
  5. Participation in a study during the past month.
Sexes Eligible for Study: All
8 Years to 16 Years   (Child)
No
Contact information is only displayed when the study is recruiting subjects
Israel
 
 
NCT00491465
rmc074301ctil
No
Not Provided
Not Provided
Not Provided
Rabin Medical Center
Not Provided
Principal Investigator: Ravital Nimri, MD Rabin Medical Center
Principal Investigator: Moshe Phillip, Prof Rabin Medical Center
Rabin Medical Center
June 2007

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP