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Study of Metronidazole and Doxycycline to Treat Oral Lichen Planus and to Compare Their Efficacy With Each Other

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00484250
First Posted: June 8, 2007
Last Update Posted: June 11, 2007
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Mashhad University of Medical Sciences
June 7, 2007
June 8, 2007
June 11, 2007
September 2005
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Complete list of historical versions of study NCT00484250 on ClinicalTrials.gov Archive Site
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Study of Metronidazole and Doxycycline to Treat Oral Lichen Planus and to Compare Their Efficacy With Each Other
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Oral lichen planus (OLP) is a chronic inflammatory disorder which causes local irritation,discomfort and subsequent poor dentition and discomfort in eating . Various treatments have been suggested for OLP but their results are unsatisfactory .Despite the fact that steroids have been the main therapeutic choice for many years,some researches have been done regarding the efficacy of other medication such as metronidazole and doxycycline.The purpose of this study is to determine whether metronidazole and doxycycline are effective in the treatment of oral lichen planus and to compare their efficacy with each other.
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Interventional
Phase 2
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double
Primary Purpose: Treatment
Oral Lichen Planus
Drug: metronidazole,doxycycline
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
20
May 2006
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Inclusion Criteria:

  • a biopsy-proven untreated OLP of every type with no symptom.

Exclusion Criteria:

  • pregnancy, presence of dysplasia in lesions,unilateral lesion suspected lichenoid reaction,history of drinking alcohol in at least 1 month prior to the study, smoking, systemic disease, use of systemic medications and hypersensitivity to the metronidazole and doxycycline.
Sexes Eligible for Study: All
Child, Adult, Senior
No
Contact information is only displayed when the study is recruiting subjects
Iran, Islamic Republic of
 
 
NCT00484250
240
Yes
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Mashhad University of Medical Sciences
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Study Chair: Arash Mansourian, DDS,MS Tehran University of Medical Sciences
Study Director: Majid Sanatkhani, DDS,MS Mashhad University of Medical Sciences
Principal Investigator: Fatemeh Momen Heravi Tehran University of Medical Sciences
Mashhad University of Medical Sciences
June 2007

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP