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fMRI of Vulnerable Brain Regions in Persons at Risk for Alzheimer's Disease (ALZ)

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00478491
First Posted: May 24, 2007
Last Update Posted: October 27, 2016
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborators:
National Institutes of Health (NIH)
National Institute on Aging (NIA)
Information provided by (Responsible Party):
University of Wisconsin, Madison
May 22, 2007
May 24, 2007
October 27, 2016
January 2003
June 2011   (Final data collection date for primary outcome measure)
Not Provided
Not Provided
Complete list of historical versions of study NCT00478491 on ClinicalTrials.gov Archive Site
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fMRI of Vulnerable Brain Regions in Persons at Risk for Alzheimer's Disease
fMRI of Vulnerable Brain Regions in Persons at Risk for Alzheimer's Disease
The purpose of this study is to investigate the organization of memory and develop future methods for early detection of AD. Using functional magnetic resonance imaging (fMRI), we examine the responsiveness of the brain to memory tasks, specifically focusing on regions of the brain (the mesial temporal lobe and posterior cingulate) that are known to be involved in early stages of Alzheimer's disease (AD). Of interest are differences in brain activation between people with and without a family history of AD and other risk factors.
Not Provided
Observational
Observational Model: Case Control
Time Perspective: Prospective
Not Provided
Retention:   Samples Without DNA
Description:
plasma and serum
Non-Probability Sample
Persons with a parent with Alzheimer's disease will be recruited from the Wisconsin Registry for Alzheimer's Prevention (WRAP). Persons with MCI will be recruited from the UW clinics and satellite clinics. Controls for the above study groups will be recruited from the WRAP and the local community.
  • Magnetic Resonance Imaging
  • Alzheimer's Disease
  • Dementia
  • Adult Children
  • Risk
Not Provided
  • 1
    Persons with a parent with Alzheimer's disease
  • 2
    Persons whose parents survived to old age without memory problems
  • 3
    Persons with diagnosed mild cognitive impairment
  • 4
    Persons without memory problems

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
390
July 2011
June 2011   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • MCI Group: Diagnosis of mild cognitive impairment
  • AD Family History Group: Confirmed family history of Alzheimer's and concurrent enrollment in the Wisconsin Registry for Alzheimer's Prevention (WRAP)
  • Control Groups: Cognitively healthy and both parents survived past age 70 with no memory problems

Exclusion Criteria:

  • Claustrophobia
  • Metallic or electronic implants or devices that are not MRI-safe
Sexes Eligible for Study: All
40 Years to 85 Years   (Adult, Senior)
Yes
Contact information is only displayed when the study is recruiting subjects
United States
 
 
NCT00478491
2002-515
NIH RO1 AG021155A
Yes
Not Provided
Not Provided
University of Wisconsin, Madison
University of Wisconsin, Madison
  • National Institutes of Health (NIH)
  • National Institute on Aging (NIA)
Principal Investigator: Sterling C Johnson, PhD University of Wisconsin/VA GRECC
University of Wisconsin, Madison
October 2016