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Curcumin for Prevention of Oral Mucositis in Children Chemotherapy

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Shoshana Vilk, Hadassah Medical Organization
ClinicalTrials.gov Identifier:
NCT00475683
First received: May 17, 2007
Last updated: August 17, 2015
Last verified: June 2011

May 17, 2007
August 17, 2015
January 2009
December 2010   (Final data collection date for primary outcome measure)
To determine whether in children undergoing doxorubicin-containing chemotherapy, does supplementation of curcumin, when compared to placebo, decrease an objective measurement of oral mucositis? [ Time Frame: 6 weeks ]
Same as current
Complete list of historical versions of study NCT00475683 on ClinicalTrials.gov Archive Site
To determine whether in children undergoing doxorubicin-containing chemotherapy, does supplementation of curcumin, when compared to placebo, decrease mucositis related pain, use of opioids and parenteral nutrition. [ Time Frame: 6 weeks ]
Same as current
Not Provided
Not Provided
 
Curcumin for Prevention of Oral Mucositis in Children Chemotherapy
Randomized Cross-over Study of Curcumin for Prevention of Oral Mucositis in Children Receiving Doxorubicin Based Chemotherapy.
Mucositis consists of inflammation of the mucosal membrane and is a prominent cause of patient discomfort during cancer therapy. In children receiving chemotherapy, the incidence of oral mucositis is reported to be between 40%-70%. Curcumin, a commonly-used spice in India and Southeast Asia, was shown in animal models to prevent chemotherapy and radiotherapy induced mucositis. We hypothesize that curcumin may prevent oral mucosal injury and reduce the severity of oral mucositis in children receiving chemotherapy. Thus, the aim of this study is to determine whether in children undergoing doxorubicin-containing chemotherapy, does supplementation of curcumin, when compared to placebo, decrease oral mucositis both by objective (mucositis scales) and subjective (pain scale) measurements. Effective prevention and reduction of mucosal injury may significantly improve the care we provide to children undergoing therapy for cancer.
Children older than 5 years of age diagnosed with cancer and treated at the Pediatric Hematology/Oncology unit, Hadassah Medical Center will be eligible to the study. The study is designed as a cross-over study, wherein each patient serves as his or her own control, thus all included children should be scheduled to receive at least two identical curses of doxorubicin-containing chemotherapy in which the dose of doxorubicin is at least 60mg/m2 per course. The patients will be assigned to randomly receive curcumin or placebo in the 1st course, with the other regimen administered at the 2nd course. Curcumin will be given as fluid extract (1:1) at a dose of 10 drops, three times a day. Adolescents and young adults will receive the adult recommend dose, i.e. 30 drops, three times a day. Placebo will be given at the same dose. The patients will be taught to rinse the mouth with the medicine and than spit out. The therapy will be given from a day prior to the first day of the cycle for two weeks. A diary kept by the family will record each given dose. Possible side effects associated with the study drug, such as vomiting, nausea, rash, etc., will be recorded. No other adjunctive topical treatment will be used during the study. Adherence will be assessed through subject reports as well as by review of returned medications every cycle collected during the objective assessment site visits. Given the intent-to-treat analysis, all participants will be included irrespective of how much of the study medication was taken.The measurements of study outcome, i.e. OMAS score, WHO mucositis scale and visual analogue pain scale will be done on day 1,7,10,14,21 ± 1 of each chemotherapy cycle. The following data will be recorded in all cycles: duration of neutropenia, the need and length of hospitalization, use and dosage of opioid analgesia, need for total potential nutrition, blood culture positive infection and other mucositis related complications.
Interventional
Phase 3
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single Blind (Outcomes Assessor)
Primary Purpose: Treatment
Chemotherapy Induced Mucositis
  • Other: Mouth wash
    Mouth wash with chlorehexidin, three times a day
  • Dietary Supplement: Curcumol
    5 ml in 50 ml water, mouthwash for 30 seconds, three times a day
  • Sham Comparator: regular measurments
    Mouth wash with chlorexidin
    Intervention: Other: Mouth wash
  • Experimental: Curucmol
    mouth wash with curcumol and mouth wash with chlorexidin
    Intervention: Dietary Supplement: Curcumol
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
8
December 2010
December 2010   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  1. Children older than 5 years of age, adolescents and young adults diagnosed with cancer and treated at the Pediatric Hematology/Oncology unit, Hadassah Medical Center,
  2. A crossover study design is planed wherein each patient serves as his or her own control, thus all included children should be scheduled to receive at least two identical curses of doxorubicin-containing chemotherapy in which the dose of doxorubicin is at least 60mg/m2 per course,
  3. Patient's/ parent's informed consent.

Exclusion Criteria:

  1. Patients treated with antiplatelet therapy or anticoagulation,
  2. Patients with biliary tract obstruction,
  3. Patients with preexisting oral disease, such as active oral infection, trauma to the oral mucosa or oral ulceration prior to chemotherapy,
  4. Patients receiving head and neck radiation,
  5. Developmentally unable to comply with curcumin mouth wash as judged by the parent or investigator.
Sexes Eligible for Study: All
5 Years to 30 Years   (Child, Adult)
No
Contact information is only displayed when the study is recruiting subjects
Israel
 
 
NCT00475683
Curcumin-HMO-CTIL
Yes
Not Provided
Not Provided
Not Provided
Shoshana Vilk, Hadassah Medical Organization
Hadassah Medical Organization
Not Provided
Principal Investigator: Shoshana Revel-Vilk, MD Hadassah Medical Center
Hadassah Medical Organization
June 2011

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP