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Genes That Affect Disease Outcome in Patients With Metastatic Colorectal Cancer

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ClinicalTrials.gov Identifier: NCT00467129
Recruitment Status : Unknown
Verified May 2007 by National Cancer Institute (NCI).
Recruitment status was:  Active, not recruiting
First Posted : April 27, 2007
Last Update Posted : December 18, 2013
Information provided by:
National Cancer Institute (NCI)

April 25, 2007
April 27, 2007
December 18, 2013
July 2002
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  • Survival
  • Progressive disease-free survival
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Complete list of historical versions of study NCT00467129 on ClinicalTrials.gov Archive Site
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Genes That Affect Disease Outcome in Patients With Metastatic Colorectal Cancer
The Role of Genetic Factors in Clinical Outcome for Colorectal Cancer

RATIONALE: Studying samples of blood and tumor tissue in the laboratory from patients with cancer may help doctors learn more about changes that occur in DNA and help doctors understand how patients respond to treatment.

PURPOSE: This clinical trial is examining genes that affect disease outcome in patients with metastatic colorectal cancer.


  • Collect blood samples for DNA extraction for genetic studies from patients receiving chemotherapy for metastatic colorectal cancer.
  • Collect detailed clinical, pathological, and chemotherapy data from these patients.
  • Identify genetic factors that relate to treatment response and outcome in these patients.

OUTLINE: Blood samples are collected and relevant genes and regions are amplified by PCR. PCR products are then sequenced or genotyped for known biological markers and single nucleotide polymorphisms. Tumor samples from surplus pathology specimens are analyzed for expression of candidate genes and mutation in the candidate genes.

Clinical and family history data is also collected by questionnaire.

PROJECTED ACCRUAL: A total of 800 patients will be accrued for this study.

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Colorectal Cancer
  • Genetic: microarray analysis
  • Genetic: mutation analysis
  • Genetic: polymerase chain reaction
  • Genetic: polymorphism analysis
  • Other: laboratory biomarker analysis
  • Other: questionnaire administration
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
Unknown status
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  • Diagnosis of metastatic colorectal cancer
  • Currently receiving chemotherapy at Weston Park Hospital


  • Not Specified


  • See Disease Characteristics
Sexes Eligible for Study: All
Child, Adult, Senior
Contact information is only displayed when the study is recruiting subjects
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University of Sheffield
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Study Chair: Angela Cox, PhD University of Sheffield
National Cancer Institute (NCI)
May 2007