Neural Networks and Language Recovery in Aphasia From Stroke: fMRI Studies

This study is currently recruiting participants. (see Contacts and Locations)
Verified February 2016 by VA Office of Research and Development
Boston University
Information provided by (Responsible Party):
VA Office of Research and Development Identifier:
First received: April 25, 2007
Last updated: February 29, 2016
Last verified: February 2016

April 25, 2007
February 29, 2016
October 1999
December 2016   (final data collection date for primary outcome measure)
Cerebral Activation in the Left and Right Brain Hemispheres [ Time Frame: Out to 6 months, from baseline entry ] [ Designated as safety issue: No ]
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Complete list of historical versions of study NCT00467103 on Archive Site
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Neural Networks and Language Recovery in Aphasia From Stroke: fMRI Studies
Neural Networks and Language Recovery in Aphasia From Stroke: fMRI Studies
The purpose of this research is to utilize functional magnetic resonance imaging (fMRI) to investigate brain reorganization for language behavior in stroke patients with aphasia. A primary focus of the study is on recovery of nonfluent propositional speech and naming in chronic aphasia patients. The fMRI technique is used to examine activation in the left hemisphere (LH) and right hemisphere (RH), during recovery of specific language behaviors in chronic nonfluent aphasia patients.

PURPOSE: The purpose of this 4-year fMRI research is to study brain reorganization for language in patients with left hemisphere (LH) stroke who have chronic nonfluent aphasia. This fMRI research is fundamental and critical to the PI's NIH RO1 grant, Transcranial Magnetic Stimulation (TMS) to Improve Speech in nonfluent aphasia, which was recently renewed for 5 years, 2006-11. There is no overlap in the studies. The NIH grant provides the TMS (real and sham). This VA grant provides 4 different fMRI tasks performed pre- and post- a series of TMS treatments (real and sham) - Overt Naming fMRI; Overt Propositional Speech fMRI; and Nonverbal Semantic Decision tasks for Nouns, and for Actions.

The investigators have observed that application of TMS to an anterior portion of right (R) Broca's homologue (pars triangularis, PTr), results in significantly improved picture naming ability at 2 and 8 Mo. after the last (10th) TMS treatment, in aphasia patients who began TMS at 5-11 years poststroke. Also, half of these nonfluent aphasia patients improved their Phrase Length in propositional speech, post-TMS.

RATIONALE: The investigators and others have observed that patients with chronic, nonfluent aphasia (poor, hesitant speech) have overactivation of R hemisphere (RH) cortical language homologues. The investigators hypothesize this represents a maladaptive plasticity and probably poor active inhibition during speech. Slow, 1 Hz TMS can be used to suppress cortical excitability. The goal is to use 1 Hz TMS to inhibit/suppress the overactivation in RH language homologues. The investigators' early TMS research has shown that suppression of R PTr in these patients is associated with improved speech. The fMRI studies proposed in this VA grant will help to investigate the neurophysiological changes underlying improvement post- TMS in propositional speech and in nonverbal semantic decision tasks. The new MRI technique, diffusion tensor imaging (DTI) will be used to study WM pathways subjacent to cortex treated with TMS.

DESIGN: Randomized, sham-control, incomplete crossover design with 32 patients (16 mild-moderate; 16 severe nonfluent), half receive real TMS series only; half, sham TMS 1st, and real 2nd. Language, Neuropsych. testing, and fMRIs are performed at Entry, and at 2 Mo. post-10 real or sham TMS treatments; and at 6 Mo. post real. There are 4 Projects: 1) fMRI during overt naming and propositional speech (Overt Picture Naming and Picture Descriptions/Story Telling; 2) fMRI during a Nonverbal Semantic Decision Task with Superordinate Noun Icons; 3) fMRI during a Nonverbal Semantic Decision Task with Action and Object Icons; 4) DTI. DTI is performed only at Entry (all subjects). Normal controls (n=8) do not receive TMS; they are studied with fMRI at Entry, at 2 and 6 Mo. later.

HYPOTHESES: Following the real TMS to suppress R PTr, there will be less overactivation on fMRI (better modulation) in RH language homologues, and new LH activation (including L perilesional areas and L SMA). This will be associated with improved propositional speech (BDAE) and nonverbal semantic decision ability at 2 and 6 Mo. post-real TMS. No language or fMRI changes are expected post-sham TMS. The fMRIs performed 3x with the normal controls are not expected to show change, but will document the neural networks for the fMRI tasks.

Observational Model: Cohort
Time Perspective: Prospective
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Non-Probability Sample
Chronic stroke patients with nonfluent aphasia
  • Aphasia
  • Nonfluent Aphasia
  • Stroke
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  • Group 1
    Chronic Stroke patients with Nonfluent Aphasia
  • Group 2
    Age-matched Normal Controls

*   Includes publications given by the data provider as well as publications identified by Identifier (NCT Number) in Medline.
December 2016
December 2016   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Aphasia patients with a single, unilateral, left hemisphere stroke.
  • Patients must be native speakers of English
  • Patients must be at least 6 months poststroke and produce mild-severe nonfluent speech. Minimum Language requirements: 2-4 word phrase length on elicited propositional speech
  • Auditory Comprehension a the 25th percentile or higher on the BDAE subtests for Word Comprehension and Commands, sufficient to cooperate during testing
  • The ability to name a minimum of 3 items on the Boston Naming Test at entry into study.
  • Patients must understand the nature of the study and give informed consent.
  • Normal right-handed controls with no history of neurological disease or substance abuse; age, education and gender-matched to the Aphasia cases.

Exclusion Criteria:

  • Patients with more than one stroke in the left hemisphere or patients with bilateral strokes.
  • Each participant must be able to have an MRI scan.
  • MRI is contraindicated for pregnant women.
  • Patients will be excluded if they have the following:
  • Intracranial metallic bodies from prior neurosurgical procedure, implanted pacemaker, medication pump, vagal stimulator, deep brain stimulator, TENS unit or ventriculoperitoneal shunt
  • Past history of seizures within one year or unexplained loss of consciousness Family history of epilepsy
  • Acute, unstable medical conditions
  • History of substance abuse (within last 6 months)
  • Abnormal neurological exam, other than as signs of the condition being studied
  • Abnormal MRI, or history of known structural brain abnormality other than as signs of the condition studied in the present protocol.
  • Administration of investigational drug within 5 halflives of the drug prior to testing.
45 Years to 80 Years
Contact: Paula I Martin, PhD BS (857) 364-4029
United States
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VA Office of Research and Development
VA Office of Research and Development
Boston University
Principal Investigator: Margaret Naeser, PhD VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA
VA Office of Research and Development
February 2016

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP