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Resistive Exercise for Arthritic Cartilage Health (REACH)

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ClinicalTrials.gov Identifier: NCT00465660
Recruitment Status : Unknown
Verified December 2006 by University of Sydney.
Recruitment status was:  Active, not recruiting
First Posted : April 25, 2007
Last Update Posted : April 25, 2007
Sponsor:
Information provided by:
University of Sydney

April 24, 2007
April 25, 2007
April 25, 2007
April 2005
Not Provided
Articular cartilage morphology following 6 months high intensity progressive resistance training
Same as current
No Changes Posted
  • Muscle and fat cross-sectional area (CSA) (pre and post)
  • Muscle strength, power, endurance, and contraction velocity (pre, 3 months, & post)
  • Medications (pre, 3 months, & post)
  • Body composition (pre, 3 months, & post)
  • Balance; Physical function (pre, 3 months, & post)
  • Questionnaires (pre, 3 months, & post):
  • Habitual exercise (PASE)
  • WOMAC index (pain, stiffness and functional ability)
  • Depressive symptoms (Depression Scale)
  • Quality of life (SF36)
  • Confidence performing physical activity (Ewart)
  • Demographics
Same as current
Not Provided
Not Provided
 
Resistive Exercise for Arthritic Cartilage Health (REACH)
The Effect of 6 Month High Intensity Progressive Resistance Training on Knee Articular Cartilage Morphology in Female Osteoarthritic Patients

Female subjects over the age of 40 will be recruited and randomised into a progressive resistance training (PRT) or sham-exercise group. The PRT group will train at 80% of their peak strength, using Keiser pneumatic resistance machines, and progress approximately 3% per session. Strength will be re-assessed fortnightly. Exercises will target muscles around the hip and knee. The sham-exercise group will train on the same equipment as the PRT group except hip adduction, but without added resistance or progression. Both groups will train 3 days per week for roughly 45 minutes for 6 months.

It is hypothesised that high intensity PRT will decelerate the tibial and femoral cartilage degeneration in the knee affected most by OA.

Primary Outcome:

Articular cartilage morphology following 6 months high intensity progressive resistance training

Secondary Outcomes:

Muscle and fat cross-sectional area (CSA) (pre and post) Muscle strength, power, endurance, and contraction velocity (pre, 3 months, & post) Medications (pre, 3 months, & post) Body composition (pre, 3 months, & post) Balance; Physical function (pre, 3 months, & post) Questionnaires (pre, 3 months, & post)

  • Habitual exercise (PASE) -WOMAC index (pain, stiffness and functional ability)
  • Depressive symptoms (Depression Scale) -Quality of life (SF36)
  • Confidence performing physical activity (Ewart) -Demographics
Not Provided
Interventional
Phase 2
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single
Primary Purpose: Treatment
Osteoarthritis
Behavioral: Progressive resistance training
Not Provided
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Unknown status
60
Same as current
July 2009
Not Provided

Inclusion Criteria:

  • Female
  • Aged over 40 years old
  • Primary Osteoarthritis in at least one knee using standard criteria of the American College of Rheumatology (ACR) criteria for classification of clinical osteoarthritis
  • Ambulatory without human assistance
  • Willingness to be randomised to experiential or control group
  • Ability to attend scheduled exercise and testing sessions

Exclusion Criteria:

  • Regular exercise of any kind over the past 3 months (>1dpw).
  • Secondary osteoarthritis (traumatic or post-surgical), rheumatic disease, gouty or septic arthritis, Paget's disease, pseudogout, major congenital abnormalities, hemochromatosis, Wilson's disease and other rare forms of arthritis
  • Joint injury, injection or surgery within the past 6 months or knee joint replacement
  • Contraindications to MRI/Exercise
Sexes Eligible for Study: Female
40 Years and older   (Adult, Older Adult)
Yes
Contact information is only displayed when the study is recruiting subjects
Australia
 
 
NCT00465660
ACTRN012605000116628
Not Provided
Not Provided
Not Provided
Not Provided
University of Sydney
Not Provided
Principal Investigator: Benedicte Vanwanseele, PhD University of Sydney
University of Sydney
December 2006

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP