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Genetic Analysis of Thyrotoxic Periodic Paralysis

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00443833
First Posted: March 6, 2007
Last Update Posted: March 6, 2007
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Ramathibodi Hospital
March 5, 2007
March 6, 2007
March 6, 2007
January 2004
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No Changes Posted
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Genetic Analysis of Thyrotoxic Periodic Paralysis
Genetic Analysis of Thai Patients With Thyrotoxic Periodic Paralysis
Thyrotoxic periodic paralysis (TPP) is characterized by episodes of reversible hypokalemia and weakness in thyrotoxic patients. It is commonly found in males of Asian descent and is also seen in individuals having Native American or Hispanic ancestry. Therefore genetic etiology has been hypothesized. This study, we aim to find the susceptibility genes that associate with TPP. Both candidate genes approach and genome wide association study have been conducted.
This study is a genetic association study. It included 50 cases of TPP patients and 80 cases of male, hyperthyroid patients who didn't have hypokalemia as a well characterized controls. After informed consent were obtained, genomic DNA from leukocyte were extracted. Pooled DNA were constructed and whole genome scan using 10K GeneChip microarray were genotyped on pooled genomic DNA.
Observational
Observational Model: Case Control
Primary Purpose: Screening
Time Perspective: Cross-Sectional
Time Perspective: Retrospective
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Thyrotoxic Periodic Paralysis
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
80
December 2005
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Inclusion Criteria:

TPP

  • Hyperthyroid patients from any causes
  • Evidence of hypokalemia (k<3.5 mg/dl)from intracellular shift (Urine K<15 mg/dl, TTKG<2)
  • Episodic paralysis

Exclusion Criteria:

  • Hypokalemia from GI or renal loss
Sexes Eligible for Study: Male
15 Years and older   (Child, Adult, Senior)
No
Contact information is only displayed when the study is recruiting subjects
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NCT00443833
11-46-21
No
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Ramathibodi Hospital
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Principal Investigator: Wallaya Jongjaroenprasert, MD Endocrinology Unit, Ramathibodi Hospital, Mahidol University
Ramathibodi Hospital
March 2007