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Metabolic Effects of Acute Cortisol Withdrawal in Adrenal Failure

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00442390
First Posted: March 1, 2007
Last Update Posted: March 1, 2007
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
University of Aarhus
February 28, 2007
March 1, 2007
March 1, 2007
January 2002
Not Provided
  • insulin sensitivity
  • local protein turnover
  • whole body protein turnover
  • glucose metabolism
  • serum metabolites
  • serum hormone levels
Same as current
No Changes Posted
Not Provided
Not Provided
Not Provided
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Metabolic Effects of Acute Cortisol Withdrawal in Adrenal Failure
Effects of Cortisol on Carbohydrate, Lipid, and Protein Metabolism; Studies of Acute Cortisol Withdrawal in Adrenocortical Failure.
Effects of adrenal steroids is generelly drawn from studies of hypercortisolism. The effects of physiological cortisol substitution and withdrawal is studied and related to the clinical syndrome of adrenal insufficiency.
Not Provided
Interventional
Not Provided
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Addison Syndrome
Drug: hydrocortisone substitution therapy versus withdrawal
Not Provided
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
10
January 2003
Not Provided

Inclusion Criteria:

  • Female adrenal failure
  • Age 18-50
  • Written informed content

Exclusion Criteria:

  • Diabetes mellitus
  • Cancer
  • Thromboembolic events
  • Pregnancy and lactation
  • Heart disease
Sexes Eligible for Study: Female
18 Years to 50 Years   (Adult)
No
Contact information is only displayed when the study is recruiting subjects
Not Provided
 
 
NCT00442390
1998/4375
No
Not Provided
Not Provided
Not Provided
University of Aarhus
Not Provided
Principal Investigator: Jens Juel Christiansen, PhD University of Aarhus
Study Chair: Claus H Gravholt, MD University of Aarhus
Study Chair: Christian B Djurhuus, PhD University of Aarhus
Study Chair: Per Iversen, PhD University of Aarhus
Study Chair: Jens S Christiansen, Professor University of Aarhus
Study Chair: Ole Schmidt, Professor University of Aarhus
Study Chair: Jørgen Weeke, Professor University of Aarhus
Study Chair: Jens OL Jørgensen, MD University of Aarhus
Study Director: Niels Møller, Professor University of Aarhus
University of Aarhus
February 2007

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP