Acute Chest Pain Treatment and Evaluation (ACTION) Study
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT00434564|
Recruitment Status : Completed
First Posted : February 13, 2007
Last Update Posted : February 10, 2017
|First Submitted Date ICMJE||February 12, 2007|
|First Posted Date ICMJE||February 13, 2007|
|Last Update Posted Date||February 10, 2017|
|Study Start Date ICMJE||August 2000|
|Primary Completion Date||Not Provided|
|Current Primary Outcome Measures ICMJE
|Original Primary Outcome Measures ICMJE||Same as current|
|Change History||Complete list of historical versions of study NCT00434564 on ClinicalTrials.gov Archive Site|
|Current Secondary Outcome Measures ICMJE
||Requirement of emergency coronary revascularisation procedures like Percutaneous Transluminal Coronary Angioplasty (PTCA) or Coronary Artery Bypass Graft (CABG)|
|Original Secondary Outcome Measures ICMJE||Same as current|
|Current Other Outcome Measures ICMJE||Not Provided|
|Original Other Outcome Measures ICMJE||Not Provided|
|Brief Title ICMJE||Acute Chest Pain Treatment and Evaluation (ACTION) Study|
|Official Title ICMJE||A Randomised Trial on Early Stress Nuclear Scan for Patients Presented to the Emergency Department (ED) With Chest Pain But Non-diagnostic Electrocardiography-Acute Chest Pain Treatment and Evaluation (ACTION) Study|
Design -prospective randomised clinical trial
-patients above 25 years of age presenting to the ED with chest pain consistent with myocardial ischaemia but with a 12 lead ECG non-diagnostic of myocardial ischaemia .
Patients were monitored continuously with a 12 lead ECG and ST segment trend monitoring and blood will be drawn at 0,3,6 hours after arrival at ED for serial myoglobin, creatine kinase MB isoenzyme (CKMB) and Troponin T (TnT) . Patients who have ECG and blood test consistent with myocardial necrosis were admitted to the CCU. A senior doctor in the ED reviewed patients who were not admitted after 6 hours of observation.
A stress tetrofosmin nuclear scan was done . Patients were then admitted and discharged depending on the results of the stress tetrofosmin scan.
Control group (conventional protocol)
Patients were then be admitted or discharged at the discretion of the senior ED doctor.
Measurement Patients were followed up at 1 week , 2 weeks , one month and six months for any adverse cardiac events such as cardiac related death , ventricular fibrillation , and myocardial infarction.
Statistical analysis Logistic regression analysis were used to compare the proportion of adverse events in the two treatment groups.
Identifying the cause of chest pain is a challenge to the Emergency Physician.Coronary artery disease is the most common group of Emergencies that has a high potential for rapidly developing a lethal outcome.
Significant proportion of patients who presented to and released from the Emergency Department (ED)with AMI or unstable angina develop poor outcomes. This is because a large proportion of AMI present atypically.The initial single 12 lead ECG done at an ED is only 50% sensitive for AMI.Serial ECGs have been shown to improve sensitivity by 25%.Because of these limitations, physicians may admit patients with chest pain, liberally. On the other hand only 25-50 % of patients admitted to CCU without AMI are eventually determined to have Acute Coronary Syndrome.
Several serum cardiac markers such as myoglobulin, CKMB and Troponin T (TnT) are found to increase sensitivity in detecting AMI than just history and ECG. Among them TnT is a better predictor of adverse cardiac event than CKMB. Absence of TnT elevation identifies a lower risk group of patients , but not necessarily a low risk group since TnT cannot detect myocardial ischaemia in the absence of myocardial injury or myocyte cell death.
There has been some chest pain evaluation practice in the ED using the graded exercise testing to screen for severe ischaemia.
Several studies have suggested the safety of exercise testing in low risk patients presenting to ED with chest pain.The use of exercise testing has been found to be a powerful tool for prognostication.
Stress nuclear imaging was also performed at the end of 6 hours of observation instead of graded exercise stress testing alone. There will be a significant proportion of patients who will not be eligible for standard exercise treadmill stress test due to poor exercise tolerance. Even for those who underwent exercise testing, studies showed that 24.2% were inconclusive because of baseline ECG abnormalities (left ventricular hypertrophy, left bundle-branch block or patient on digoxin). Some patients may not be able to achieve the required exercise level.
Studies have shown that the mean sensitivity and specificity for graded exercise testing to detect severe coronary artery disease were 68 and 77% respectively. The sensitivity of graded exercise test for detecting single vessel disease is lower.
Stress nuclear imaging is valuable in establishing the prognosis of patients with a low likelihood of coronary artery disease. Stress nuclear scans have additive prognostic value to graded exercise test especially if the latter is abnormal or non-diagnostic.For those who cannot exercise, pharmacological stress tetrofosmin with dobutamine or adenosine will be performed instead.
The efficacy of acute chest pain evaluation centre has not been compared with a conventional protocol in a prospective randomised clinical trial.
5. Treatment Plan
First 6 hours Once informed consent was obtained, the patient was then enrolled. They were put on continuous ECG monitoring. Ten mls of blood were drawn at 0,3,6 hours after arrival at the ED for myoglobin, CKMB and TnT analysis. Blood for LDL & HDL were also drawn at 0 hour as well with the cardiac markers. The old hospital case record of patient, if available, were retrieved and previous ECG's were also compared against the new ECG.
Patients who develop recurring chest pain consistent with myocardial ischaemia, ST segment elevation or depression on continuous 12 lead ECG monitoring indicating myocardial necrosis, or have positive CKMB (> 5), Troponin T (> 0.01), were admitted to the Department of Cardiology. If the patient was not admitted at the end of 6 hours, he/she were reviewed by a ED Registrar/Associate Consultant/Consultant. The senior ED doctor reviewed the patient, his/ her 12 lead ECGs and blood results for serum markers for myocardial necrosis.
After first 6 hours - Study Group (Intervention Protocol)
The patient then underwent a stress tetrofosmin scan within 24 hours of presentation (exercise or pharmacological stress for those who cannot exercise). Tetrofosmin scans was be done at NHC or the Department of Nuclear Medicine, SGH. Patients were monitored until the test was completed. If the stress tetrofosmin scan turned out to be positive, the patient was then admitted to the hospital for further management. If the stress tetrofosmin scan was negative, the patient was released from ED with instructions for follow-up in the cardiology clinic as an outpatient.
Control Group (conventional protocol) The patient with high or intermediate risk for coronary artery disease (CAD) as defined by Agency for HealthCare Policy and Research guidelines for Unstable Angina was admitted. The indicators for coronary artery disease are definite angina, T wave inversion> 1 mm in leads with dominant R waves and diabetes. If in doubt, patients were also admitted. Patients who were discharged from the ED will be reviewed by a cardiologist at the NHC cardiac clinic within two weeks.
6. Follow Up
Patients were followed up at one month, six months and one year for any primary or secondary endpoints.
|Study Type ICMJE||Interventional|
|Study Phase||Phase 4|
|Study Design ICMJE||Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
|Condition ICMJE||Chest Pain|
|Intervention ICMJE||Procedure: Stress nuclear scan|
|Study Arms||Not Provided|
* Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
|Recruitment Status ICMJE||Completed|
|Original Enrollment ICMJE||Same as current|
|Study Completion Date||May 2002|
|Primary Completion Date||Not Provided|
|Eligibility Criteria ICMJE||
|Ages||25 Years and older (Adult, Senior)|
|Accepts Healthy Volunteers||No|
|Contacts ICMJE||Contact information is only displayed when the study is recruiting subjects|
|Listed Location Countries ICMJE||Singapore|
|Removed Location Countries|
|NCT Number ICMJE||NCT00434564|
|Other Study ID Numbers ICMJE||NMRC/0517/2001|
|Has Data Monitoring Committee||Not Provided|
|U.S. FDA-regulated Product||Not Provided|
|IPD Sharing Statement||Not Provided|
|Responsible Party||Singapore General Hospital|
|Study Sponsor ICMJE||Singapore General Hospital|
|PRS Account||Singapore General Hospital|
|Verification Date||February 2017|
ICMJE Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP