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Effect Of Nicotine on Neurocognitive Performance of Cigarette Smokers

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified January 2007 by Hadassah Medical Organization.
Recruitment status was:  Not yet recruiting
Information provided by:
Hadassah Medical Organization Identifier:
First received: January 30, 2007
Last updated: NA
Last verified: January 2007
History: No changes posted

January 30, 2007
January 30, 2007
February 2007
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Neurocognitive functions
Same as current
No Changes Posted
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Effect Of Nicotine on Neurocognitive Performance of Cigarette Smokers
Effect Of Nicotine on Neurocognitive Performance of Cigarette Smokers: A Double-Blind, Within-Subjects, Placebo-Controlled Study
This research project addresses the hypothesis that a neurocognitive profile characterized by impairment of response inhibition and sustained attention may be a risk factor for smoking initiation and nicotine dependence among young women. Nicotine has short- term, facilitating effects on attention and response inhibition. Therefore, individuals who are impaired on cognitive functions such as these and initiate cigarette smoking may be more likely to maintain the habit and develop nicotine dependence. The research protocol specifically tests whether administration of nicotine to non-abstinent, regular cigarette smokers improves cognitive function in those domains where the participants had previously been shown to manifest performance deficits
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Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: Double-Blind
Primary Purpose: Diagnostic
  • Nicotine Dependence
  • Smoking
  • Tobacco Use Disorder
  • Nicotine Use Disorder
Drug: Nicotine
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Yakir A, Rigbi A, Kanyas K, Pollak Y, Kahana G, Karni O, Eitan R, Kertzman S, Lerer B. Why do young women smoke? III. Attention and impulsivity as neurocognitive predisposing factors. Eur Neuropsychopharmacol. 2007 Apr;17(5):339-51. Epub 2006 Nov 30.

*   Includes publications given by the data provider as well as publications identified by Identifier (NCT Number) in Medline.
Unknown status
April 2007
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Inclusion Criteria:

  • Reported smoking cigarettes on a daily basis at the time of the original study and continue to smoke currently
  • Manifested poor performance on the MFFT (The neurocognitive test that yielded differences between smokers and non-smokers)
  • Competent and willing to give written informed consent

Exclusion Criteria:

  • Pregnancy, breast-feeding, non-use of contraception such that the possibility of pregnancy cannot be excluded
  • Intake of any medication that may potentially interact with nicotine.
  • Any current or past medical condition that represents a contra-indication to nicotine administration.
Sexes Eligible for Study: Female
18 Years to 30 Years   (Adult)
Contact information is only displayed when the study is recruiting subjects
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Hadassah Medical Organization
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Principal Investigator: Avi Yakir, MD Hadassah Medical Organization
Hadassah Medical Organization
January 2007

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP