We updated the design of this site on September 25th. Learn more.
Show more
ClinicalTrials.gov
ClinicalTrials.gov Menu

Oral Human Papillomavirus Infection in HIV-infected Men

This study is currently recruiting participants.
Verified January 2016 by Alexander Kreuter, Deutsche Luft und Raumfahrt
Sponsor:
ClinicalTrials.gov Identifier:
NCT00421486
First Posted: January 12, 2007
Last Update Posted: January 21, 2016
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.
Information provided by (Responsible Party):
Alexander Kreuter, Deutsche Luft und Raumfahrt
January 10, 2007
January 12, 2007
January 21, 2016
March 2006
January 2017   (Final data collection date for primary outcome measure)
Spectrum of HPV types and associated clinical lesions [ Time Frame: swabs will be obtained approximately every 6 months ]
Not Provided
Complete list of historical versions of study NCT00421486 on ClinicalTrials.gov Archive Site
Not Provided
Not Provided
Not Provided
Not Provided
 
Oral Human Papillomavirus Infection in HIV-infected Men
Incidence, Prevalence, Spectrum of HPV-types, and Viral Load Determination of High-risk Human Papillomavirus Infection of the Oral Cavity in HIV-infected Men Who Have Sex With Men
Human papillomavirus (HPV)-infection belong to the most common sexually transmitted diseases worldwide. HIV-infected men having sex with men /MSM) are strongly associated with a higher prevalence of genitoanal HPV-infection, and perianal HPV-infections have been detected in up to 90% of HIV-positive men. The data concerning the incidence of oral HPV-infection in HIV-positive men, especially in the era of highly antiretroviral therapy, are conflicting. Thus, this prospective study mainly focuses on the incidence and prevalence of oral HPV-infection, spectrum of HPV-types, and oral high-risk HPV viral load in HIV-positive men.
Human papillomavirus (HPV)-infection belong to the most common sexually transmitted diseases worldwide. Estimated prevalences of subclinical genital HPV-infection in the immunocompetent sexually active population range from 10 to above 50%. Genetic or iatrogenic immunosuppression is known to play a decisive role in the initiation of a variety of cutaneous neoplasias and their precursor lesions. In this context, HPV-associated anogenital malignancies occur with high frequency in patients with HIV-infection. In several studies, perianal HPV-infections have been detected in up to 90% of HIV-positive men and a high incidence of anal dysplasia has been reported in these patients. The data concerning the incidence of oral HPV-infection in HIV-positive men, especially in the era of highly antiretroviral therapy, are conflicting. Thus, this prospective study mainly focuses on the incidence and prevalence of oral HPV-infection, spectrum of HPV-types, and oral high-risk HPV viral load in HIV-positive men.
Observational
Observational Model: Case Control
Time Perspective: Prospective
Not Provided
Not Provided
Probability Sample
HIV-infected men who have sex with men
  • Papillomavirus Infections
  • HIV Infections
Procedure: Oral swabs for HPV-typing and high-risk HPV-determination
Oral swabs for HPV-typing and high-risk HPV-determination
Not Provided
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
500
January 2018
January 2017   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • HIV-infected men who have sex with men

Exclusion Criteria:

Sexes Eligible for Study: Male
18 Years and older   (Adult, Senior)
Yes
Contact: Alexander Kreuter, MD 0049/234/5093439 a.kreuter@derma.de
Germany
 
 
NCT00421486
01 KI 0501
Not Provided
Not Provided
Not Provided
Alexander Kreuter, Deutsche Luft und Raumfahrt
Deutsche Luft und Raumfahrt
Not Provided
Principal Investigator: Alexander Kreuter, MD Department of Dermatology, Ruhr University Bochum
Principal Investigator: Norbert Brockmeyer, MD Department of Dermatology, Ruhr University Bochum
Principal Investigator: Ulrike Wieland, MD Institute of Virology, University of Cologne
Deutsche Luft und Raumfahrt
January 2016