Double-Blind, Multicenter, Sham Surgery Controlled Study of CERE-120 in Subjects With Idiopathic Parkinson's Disease

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00400634
Recruitment Status : Completed
First Posted : November 17, 2006
Results First Posted : August 14, 2012
Last Update Posted : August 14, 2012
Information provided by (Responsible Party):

November 15, 2006
November 17, 2006
May 24, 2012
August 14, 2012
August 14, 2012
November 2006
November 2008   (Final data collection date for primary outcome measure)
UPDRS Part III OFF [ Time Frame: Change from Baseline to 12 Month Visit ]
The UPDRS (Unified Parkinson's Disease Rating Scale) is a clinical rating scale that assesses the symptomatic burden of Parkinson's Disease. The scale has four main sections, and each item is scored from a 0 to a 4 (higher number is more severe manifestation). Part III is a subsection devoted to motor function, has 14 questions, resulting in a score range of 0 (unaffected) to 56 (severely affected). The scale is administered by a trained clinician, and patients were assessed in a practically defined "off" condition, 12 hours or more after the last administration of medication.
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Complete list of historical versions of study NCT00400634 on Archive Site
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Double-Blind, Multicenter, Sham Surgery Controlled Study of CERE-120 in Subjects With Idiopathic Parkinson's Disease
Multicenter, Randomized, Double-Blind, Sham Surgery-Controlled Study of CERE-120 (Adeno-Associated Virus Serotype 2 [AAV2]-Neurturin [NTN]) to Assess the Efficacy and Safety of Bilateral Intraputaminal (IPu) Delivery in Subjects With Idiopathic Parkinson's Disease
The purpose of this double blind study is to determine whether CERE-120 (adeno-associated virus serotype 2 [AAV2]-neurturin [NTN]) is effective and safe in the treatment of patients with idiopathic Parkinson's Disease. CERE-120 is administered via bilateral stereotactic injections targeting the putaminal region of the brain. The design of this study involves approximately 34 patients receiving CERE-120 treatment via stereotactic surgery and approximately 17 patients receiving sham stereotactic surgery (no CERE-120 administered).
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Phase 2
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary Purpose: Treatment
Idiopathic Parkinson's Disease
  • Genetic: CERE-120 (Adeno-Associated Virus Serotype 2 [AAV2]-Neurturin [NTN])
    CERE-120 5.4 x 10^11 vg
  • Procedure: Sham Surgery
    Bilateral partial thickness burr holes placed, no intraparenchymal injections
  • Experimental: 1
    Intracerebral administration of CERE-120
    Intervention: Genetic: CERE-120 (Adeno-Associated Virus Serotype 2 [AAV2]-Neurturin [NTN])
  • Sham Comparator: 2
    Sham Neurosurgery
    Intervention: Procedure: Sham Surgery
Marks WJ Jr, Bartus RT, Siffert J, Davis CS, Lozano A, Boulis N, Vitek J, Stacy M, Turner D, Verhagen L, Bakay R, Watts R, Guthrie B, Jankovic J, Simpson R, Tagliati M, Alterman R, Stern M, Baltuch G, Starr PA, Larson PS, Ostrem JL, Nutt J, Kieburtz K, Kordower JH, Olanow CW. Gene delivery of AAV2-neurturin for Parkinson's disease: a double-blind, randomised, controlled trial. Lancet Neurol. 2010 Dec;9(12):1164-1172. doi: 10.1016/S1474-4422(10)70254-4. Epub 2010 Oct 20.

*   Includes publications given by the data provider as well as publications identified by Identifier (NCT Number) in Medline.
November 2008
November 2008   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • Diagnosis of bilateral, idiopathic Parkinson's Disease (PD) based on UK Brain Bank criteria with motor complications despite adequate oral antiparkinsonian therapy.
  • At least 5 years disease duration, relative to the anticipated date of surgery, since diagnosis of PD.
  • Males or nonpregnant females 35-75 years of age, inclusive.
  • A UPDRS motor scale score of 30 or greater in the practically defined off condition during the 30-day eligibility evaluation period.
  • Stable doses of antiparkinsonian medications and parkinsonian features for the 60-day period preceding the surgical procedure.
  • No conditions that would render the subject unsuitable for surgery, or that would interfere with any of the assessments of efficacy or safety in this trial.
  • Subject's informed consent prior to the performance of any study-specific procedures.

Exclusion Criteria:

  • Subjects with atypical or secondary parkinsonism.
  • Any subject, in the judgment of the investigator, for whom participation in the study would pose a safety risk including, but not limited to, a history of any clinically significant medical, psychiatric, or laboratory abnormality.
  • History of treatment of PD by any procedure involving intracranial surgery or implantation of a device.
  • MRI of the brain within 12 months before the surgical procedure that indicates the presence of an abnormality that may interfere with the assessments of safety or efficacy or would, in the judgment of the investigator, represent a surgical risk to the subject.
  • Any disorder that precludes a surgical procedure (e.g., signs of sepsis or inadequately treated infection) or alters wound healing.
  • Receipt of antiplatelet agents for at least 10 days prior to the surgical procedure.
  • A score of less than or equal to 27 on the Folstein Mini-Mental examination performed during the eligibility evaluation period or clinical evidence of cognitive impairment that would affect the subject's ability to sign the informed consent or perform any of the protocol required assessments.
  • Chemotherapy, cytotoxic therapy, or immunotherapy within 6 weeks prior to the surgical procedure.
  • Vaccinations within 30 days prior to the surgical procedure.
  • History, within 2 years before the surgical procedure, of drug or alcohol abuse.
  • Treatment with neuroleptics within 1 year before the surgical procedure.
  • Any medical disability (e.g., severe degenerative arthritis, compromised nutritional state, peripheral neuropathy) that would interfere with the assessment of efficacy and safety in this trial or would compromise the ability of the subject to undergo study procedures (e.g., MRI, PET), or give informed consent.
  • History of prior gene transfer therapy.
  • Treatment with an investigational agent within 60 days before the surgical procedure.
Sexes Eligible for Study: All
35 Years to 75 Years   (Adult, Older Adult)
Contact information is only displayed when the study is recruiting subjects
United States
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Study Director: Joao Siffert, M.D. Ceregene
July 2012

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP