University of Michigan "Nephrology Research BioBank"

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details. Identifier: NCT00381121
Recruitment Status : Recruiting
First Posted : September 27, 2006
Last Update Posted : October 24, 2018
Information provided by (Responsible Party):
Matthias Kretzler, University of Michigan

September 26, 2006
September 27, 2006
October 24, 2018
September 2006
August 2026   (Final data collection date for primary outcome measure)
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Complete list of historical versions of study NCT00381121 on Archive Site
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University of Michigan "Nephrology Research BioBank"
Michigan Nephrology Research BioBank for Molecular Analysis of Renal Disease "Nephrology Research BioBank"
The purpose of the study is to create a Nephrology Tissue Biobank enabling the study of kidney disease from the perspectives of epidemiology, genetics and molecular biology.

Each year chronic kidney disease (CKD) claims the lives of millions of people worldwide. Costs for patient care are in excess of 2.4 billion dollars in the US alone. At the moment most kidney diseases are of unknown etiology, are classified according to a microscopic description of the kidney tissue obtained on biopsy and are treated with non-specific therapies.

Each kidney contains millions of filter units called nephrons. The nephron consists of a glomerulus and a tubule. The glomerulus filters the blood of waste products, while retaining larger molecules that are required for the body to function properly. The filtered fluid then passes through the tubule, where salts, acids and water are regulated to keep the body in a normal metabolic state. After the filtered fluid passes through the tubule it is collected in the bladder as urine. Diseases, which affect the glomeruli or tubules result in kidney damage. Once kidney function is lost it is generally not recoverable and the only option for a patient's survival is dialysis or transplantation.

The purpose of this study is to provide a platform, which will enable researchers with different areas of expertise, to investigate the molecular markers and pathways of kidney disease and its progression. Our goal is to increase our understanding of kidney health issues and to develop new prevention and treatment strategies which will be shared with the medical community and the public.

Study description:

Individuals seen in the nephrology clinic at the University of Michigan will be eligible to enroll in this study. Their clinical data will be recorded, blood and urine samples will be collected and if a biopsy is performed as a part of their standard medical care then a small sample will be reserved for use in the study after all pathological evaluations required for patient care are completed. Biological samples will be available for biochemical, molecular biological and genetic testing and for correlation of these parameters to the individuals clinical data in future studies.


Advances in the understanding of kidney disease may 1) provide methods of early detection of disease, 2) identify molecular markers that will help physician prescribe the most appropriate and beneficial treatments, 3) identify targets for the development of new treatments, and 4) decrease the enormous cost of caring for individuals with CKD.


  1. Create a biobank enabling the study of kidney disease from the perspectives of epidemiology, genetics and molecular biology.
  2. Create a resource for the study of kidney disease, which will enable the researchers at the University of Michigan to work collaboratively toward the elucidation of the molecular pathways, which cause kidney disease.
Observational Model: Cohort
Time Perspective: Prospective
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Retention:   Samples With DNA
Tissue, blood, urine
Non-Probability Sample
Renal disease patients undergoing diagnostic workup
Chronic Kidney Disease
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Kidney disease cohort
Individuals with a clinically indicated biopsy are recruited and/or surplus tissue that remains from past clinical interventions is obtained.
Schmid H, Henger A, Kretzler M. Molecular approaches to chronic kidney disease. Curr Opin Nephrol Hypertens. 2006 Mar;15(2):123-9. Review.

*   Includes publications given by the data provider as well as publications identified by Identifier (NCT Number) in Medline.
Same as current
August 2026
August 2026   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • Men, women and children undergoing kidney and/or pancreas biopsy at the University of Michigan

Exclusion Criteria:

  • Individuals not willing to provide consent (for prospective biopsy)
Sexes Eligible for Study: All
Child, Adult, Older Adult
Contact: Chrysta Lienczewsky 734-764-2924
United States
HUM 4729
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Matthias Kretzler, University of Michigan
University of Michigan
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Principal Investigator: Matthias Kretzler,, MD University of Michigan
University of Michigan
October 2018