Physical Activity After Stroke: How Does it Effect Chronical Inflammation and Insulin Sensitivity

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00376207
Recruitment Status : Completed
First Posted : September 14, 2006
Last Update Posted : October 17, 2007
Information provided by:
Bispebjerg Hospital

September 13, 2006
September 14, 2006
October 17, 2007
January 2006
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  • Association between PASE and HOMA
  • Association between PASE and IL-6
Same as current
Complete list of historical versions of study NCT00376207 on Archive Site
  • IL-6 concentration is lower in the intervention group than control group.
  • TNF-alfa and IL-6 is positively associated.
  • IL-18 is associated to HOMA
  • Correlation between PASE and HOMA in the intervention group vs. controls
  • HOMA mean value in the 2 groups
Same as current
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Physical Activity After Stroke: How Does it Effect Chronical Inflammation and Insulin Sensitivity
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Decreased insulin sensitivity is and independent risk factor for stroke despite glycemic control. It is known that physical exercise increases insulin sensitivity in healthy subjects. Wether stroke patients can increase insulin sensitivity via physical exercise is not known.

Chronic low-grade inflammation is associated with an increased risk of stroke. Physical exercise has shown to increase IL-6 directly after exercise in untrained subjects. When fitness is increased in each subject then the peak IL-6 concentration after exercise decreases and so does the basal level of IL-6. It is not known whether stroke patients can increase physical activity level to a degree where chronic inflammation are decreased.

This study is designed to evaluate if physical exercise after stroke will increases insulin sensitivity and reduce low-grade chronic inflammation.

Stroke patients have been randomized to intervention with physical exercise or control in the ExStroke pilot trial and followed for 2 years. Using the study population from the ExStroke pilot trail blood samples will be obtained at the last control. Insulin sensitivity can be measured from fasting glucose and insulin using the Homeostasis Model Assessment (HOMA). Interleukin-6, TNF-alfa and CRP is measured to estimate chronic inflammation.

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Not Applicable
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Single
Primary Purpose: Prevention
Cerebral Infarction
Behavioral: Physical exercise
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*   Includes publications given by the data provider as well as publications identified by Identifier (NCT Number) in Medline.
Same as current
August 2007
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Inclusion Criteria:

  • participated in the ExStroke Pilot trail

Exclusion Criteria:

  • Diabetes Mellitus
  • Not able to give informed consent
Sexes Eligible for Study: All
40 Years and older   (Adult, Senior)
Contact information is only displayed when the study is recruiting subjects
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Bispebjerg Hospital
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Principal Investigator: Lars-Henrik Krarup, MD Bispebjerg Hospital
Bispebjerg Hospital
October 2007

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP