Effect of Samarium on the Relief of Pain Due to Vertebral Metastases

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
Hani Ashamalla, New York Methodist Hospital
ClinicalTrials.gov Identifier:
NCT00374751
First received: September 8, 2006
Last updated: April 27, 2015
Last verified: April 2015

September 8, 2006
April 27, 2015
May 2006
January 2014   (final data collection date for primary outcome measure)
To determine the effect of intravertebral injection of Samarium on the relief of pain [ Time Frame: 6 months ] [ Designated as safety issue: Yes ]
To determine the effect of intravertebral injection of Samarium on the relief of pain
Complete list of historical versions of study NCT00374751 on ClinicalTrials.gov Archive Site
To evaluate the effect of this procedure on the size of the vertebral metastatic deposits [ Time Frame: 6 months ] [ Designated as safety issue: Yes ]
To evaluate the effect of this procedure on the size of the vertebral metastatic deposits
Not Provided
Not Provided
 
Effect of Samarium on the Relief of Pain Due to Vertebral Metastases
Phase I/II Study of the Use of Vertebral Intracavitary Cement and Samarium (VICS) for Painful Vertebral Metastases

Cancer cells may spread from the primary site to the vertebrae resulting in their deformity. The standard treatment for this case is removal of the cancer deposits in the vertebra and filling the induced cavity with a cement like substance.

We are studying the effects (good or bad) of adding samarium (a radioactive substance) to the cement that is injected into the induced cavity.

Protocol:

  1. Patients with bone metastases will be identified and discussed in the weekly joint Neuroscience meeting held in Radiation Oncology Department.
  2. If the patient is eligible to this study, the protocol will be offered to him/her. If the patient accepts; informed consent will be obtained.
  3. The case will be scheduled jointly by Neurosurgeon and Radiation Oncologist.
  4. Radiation physicist orders the radioactive samarium.

During the procedure:

  1. Neurosurgical procedure ( kyphoplasty/vertebroplasty) is performed as standard using . mild general sedation and local anesthesia.
  2. Once a cavity is identified in fluoroscopy, the trocar is secured. The volume and pressure of the kyphoplasty balloon are recorded.
  3. According to standard practice; only the radiation team (Radiation oncologist, Physicist) is handling the radioactive material. All work is done under sterile conditions.
  4. Two mCi. of Samarium is prepared after serial dilution steps under radiation precautions in the department of radiation oncology and material is transferred to OR.
  5. 0.5ml of "Head Cement" is administered first to act as a seal.
  6. The Samarium is then introduced into the vertebral cavity using a 2-way valve by the Radiation Oncologist. Total of 0.5ml (Samarium+0.2ml radio opaque material)
  7. The "Foot cement" (0.5 ml) is then introduced via the same 2-way valve into the vertebral cavity by the neurosurgeon to flush any remains of radioactivity in the system.
  8. The two way valve is then removed and the rest of kyphoplasty/vertebroplasty is ensued as per their ordinary protocol.
  9. Final volume of cement injected is recorded.
  10. After securing the wound, all devices, syringes, gloves and basins used for handling the radioactive substance are collected in a "red bag" and stored by radiation safety officer in the hot lab. till full radioactive decay.
  11. The room is scanned after patient's discharge, any spillage should be reported to radiation safety officer and normal procedures for environmental protection are ensued.

Post Procedure:

  1. Normal neurosurgical recovery room protocol is employed. No radiation precautions needed.
  2. Patient can be discharged home. No delays because of radiation precautions
  3. Once patient is cleared, a nuclear imaging scan is obtained with Gamma camera. The ratio of uptake in the vertebra to background is calculated. Moreover, Full body scan is obtained to identify other areas of uptake if any.
  4. A second nuclear imaging scan is done on the 4th day of the procedure (Two half Lives) to document significant decay and calculate dose.
  5. MRI/CT scan of the area treated should be done in 4 weeks to assess outcome.
  6. Clinical follow up is obtained at 2, 4 weeks and in 3 months. Careful pain score assessment is included in each time (Use Study Flow Sheet)
Interventional
Phase 1
Phase 2
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
  • Cancer
  • Metastasis
  • Pain
Drug: Samarium (153SM)
The Samarium is introduced into the vertebral cavity using a 2-way valve by the radiation oncologist. The cement is then introduced via the same 2-way valve into the vertebral cavity by the neurosurgeon.
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Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
29
Not Provided
January 2014   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • The patient must be 18 years of age or older
  • The patient must have histologically proven malignancy in the primary site (breast, prostate, or lung)
  • The patient must have a radiographic evidence of bone metastasis, and this must have been performed within 8 weeks prior to enrollment in the study. Acceptable studies include plain radiographs, radionuclide bone scans, computed tomography scans, magnetic resonance imaging, and PET-CT scans.
  • The patient must have an intact anterior wall of spinal canal
  • The patient must have significant pain (score 6 or above,)which appears to be related to the radiographically documented metastatic vertebra(e) in concern, as measured by the "Visual Analog Scale"
  • The patient must be surgically and medically accepted for vertebroplasty/kyphoplasty operation
  • Karnofsky Performance status >40
  • Expected life expectancy of 6 months or greater, as estimated by the physician in charge.
  • The patient must sign a study specific informed consent prior to enrollment

Exclusion Criteria:

  • Epidural soft tissue component
  • Patients with vertebral metastases and with clinical or radiographic evidence of spinal cord or cauda equina impingement (effacement) or compression
  • Inability to undergo anesthesia
  • Hematologic primary malignancies Patients received systemic radiotherapy (89SR or 153SM)within 30 days prior to enrollmen
Both
18 Years to 80 Years
No
Contact information is only displayed when the study is recruiting subjects
United States
 
NCT00374751
NYM-354
Yes
Hani Ashamalla, New York Methodist Hospital
New York Methodist Hospital
Not Provided
Principal Investigator: Hani Ashamalla, MD, FCCP New York Methodist Hospital
New York Methodist Hospital
April 2015

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP