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Study of the Relationship Between Blood Vessels and Insulin Response in Adolescents

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ClinicalTrials.gov Identifier: NCT00374361
Recruitment Status : Completed
First Posted : September 11, 2006
Last Update Posted : June 8, 2016
Nationwide Children's Hospital
Information provided by (Responsible Party):
Robert Hoffman, Ohio State University

September 7, 2006
September 11, 2006
June 8, 2016
July 2003
June 2006   (Final data collection date for primary outcome measure)
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Complete list of historical versions of study NCT00374361 on ClinicalTrials.gov Archive Site
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Study of the Relationship Between Blood Vessels and Insulin Response in Adolescents
Relationship of Endothelial Function to Insulin Sensitivity in African American and Caucasian Adolescents
This study is designed to determine whether there is a relationship between the way insulin and blood vessels work. The difference in the interaction between Caucasian and African American adolescents will also be examined. This may play a role in the differing rates of heart disease and diabetes between the two groups.

Purpose: The purpose of the research is to learn more about how the lining of arteries in the body (called the endothelium) and insulin work in adolescents. Abnormalities in how the blood vessels and insulin work in adolescents may cause high blood pressure, type 2 diabetes, stroke and heart disease.

Healthy adolescents between 8 and 18 years of age are being studied in the Ohio State University General Clinical Research Center. Two visits will be necessary. One will be a screening visit to determine the child's stage of puberty and obtain a medical history. The second will be the study visit. During the latter, blood vessel function will be determined by studying the change in forearm blood flow before and after blood flow to the forearm is stopped. Insulin sensitivity will be determined using glucose water given into a vein.

Observational Model: Cohort
Time Perspective: Prospective
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Probability Sample
  • Diabetes Mellitus, Type 2
  • Hypertension
  • Heart Disease
  • Stroke
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  • Caucasian Adolescents
    Caucasian Adolescents
  • African-American Adolescents
    African-American Adolescents

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
June 2006
June 2006   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • Caucasian or African American adolescent
  • Between 8 and 18 years of age

Exclusion Criteria:

  • Pregnancy
  • Chronic Disease
  • Acute Disease
  • Medication Requirement
Sexes Eligible for Study: All
8 Years to 18 Years   (Child, Adult)
Contact information is only displayed when the study is recruiting subjects
United States
ENDO 203
AHA 0355195B ( Other Grant/Funding Number: American Heart Association )
Not Provided
Plan to Share IPD: No
Plan Description: Observational
Robert Hoffman, Ohio State University
Ohio State University
Nationwide Children's Hospital
Study Chair: Robert P Hoffman, MD Ohio State University
Ohio State University
June 2016