Irbesartan, Ciprofibrate and Their Combination Onto the Endothelial Functions

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00350038
Recruitment Status : Completed
First Posted : July 10, 2006
Last Update Posted : January 23, 2008
Bristol-Myers Squibb
Information provided by:

July 7, 2006
July 10, 2006
January 23, 2008
February 2005
Not Provided
Microvascular reactivity
Same as current
Complete list of historical versions of study NCT00350038 on Archive Site
  • Reach of target blood pressure
  • Measurements of safety laboratory parameters
Same as current
Not Provided
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Irbesartan, Ciprofibrate and Their Combination Onto the Endothelial Functions
Investigations of the Effects of Aprovel, Lipanor and Their Combination Onto the Endothelial Functions of Dyslipidemic Patients Measure by Laser Doppler Flow-Metry.
The rationale of the study is to clarify whether the supplementation of irbesartan with ciprofibrate could increase the antihypertensive effect, could improve the endothelial functions, and/or could affect the atherogenic small-dense LDL-, oxydized LDL concentrations, onto the paraoxinase activity and on the CRP and insulin levels.
Not Provided
Phase 4
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
  • Hypertension
  • Dyslipidemia
  • Drug: Irbesartan
  • Drug: Ciprofibrate
Not Provided
Not Provided

*   Includes publications given by the data provider as well as publications identified by Identifier (NCT Number) in Medline.
Same as current
August 2007
Not Provided

Inclusion Criteria:

  • hypertensive + dyslipidemic + damaged endothelial function

Exclusion Criteria:

  • hepatic and kidney damage,
  • IDDM (Insulin Dependent Diabetes Mellitus)
  • Freckson V type hyperlipoproteinaemia

The above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.

Sexes Eligible for Study: All
45 Years to 70 Years   (Adult, Older Adult)
Contact information is only displayed when the study is recruiting subjects
Not Provided
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Bristol-Myers Squibb
Study Director: László Erős, MD Sanofi-aventis, Hungary
January 2008

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP