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Partnership Programs to Reduce Cardiovascular Disparities- Morehouse- Emory Partnership (Meta-Health)

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ClinicalTrials.gov Identifier: NCT00336869
Recruitment Status : Completed
First Posted : June 14, 2006
Last Update Posted : November 18, 2013
Information provided by (Responsible Party):

June 12, 2006
June 14, 2006
November 18, 2013
December 2005
January 2010   (Final data collection date for primary outcome measure)
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Complete list of historical versions of study NCT00336869 on ClinicalTrials.gov Archive Site
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Partnership Programs to Reduce Cardiovascular Disparities- Morehouse- Emory Partnership
Partnership Programs to Reduce Cardiovascular Disparities- Morehouse- Emory Partnership
The theme of this Morehouse-Emory Partnership Program focuses on elucidating the etiologic basis of ethnic differences in obesity-related CVD and discovering new intervention strategies to ameliorate CV health in all communities. The proposed Program uses a multi-disciplinary strategy to systematically characterize ethnic differences in obesity-related CVD by drawing upon the fields of physiology, psychology, biochemistry, vascular biology, public health, nursing and clinical medicine.

Emerging evidence indicates that there are ethnicity-specific differences in the profile of biochemical, metabolic and physiological perturbations associated with obesity. The implications of these ethnic differences remain to be further defined. Several epidemiologic studies have shown that vascular disease and its cardiovascular complications, carry significantly higher morbidity and mortality in African Americans compared with Caucasians.1-3 These observations may be partly explained by a higher prevalence of cardiovascular disease risk factors, such as essential hypertension, diabetes mellitus, and tobacco use among African Americans.4-6 However, the pathophysiological processes underlying this racial predisposition have not been fully elucidated.7 It is likely that the etiologic basis of ethnic disparities in cardiovascular disease is multi-factorial and involves dynamic gene-environment interactions in which variances in behavior and the social context are critical determinants.

The proposed Program recognizes the importance of incorporating both biological factors and social determinants in the analysis of cardiovascular disparities

Observational Model: Cohort
Time Perspective: Cross-Sectional
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Retention:   Samples Without DNA
Blood samples metabolic testing
Non-Probability Sample
African American and White residents age 30-65
Metabolic Syndrome
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
January 2010
January 2010   (Final data collection date for primary outcome measure)

Inclusion Criteria:

Our methodological approach will involve a random digit-dialing cross-sectional survey of 4000 Metro Atlanta area AA and white residents (ages 30-65 years). This aim will focus on using well-validated survey instruments to examine self-reported perceptions of psychosocial stress, neighborhood segregation factors and health beliefs related to weight/weight control. These parameters will be assessed in relation to the differential prevalence of three major outcomes: (1) self-reported maladaptive cardiovascular behaviors that predispose to obesity-related CVD (ie high fat/sodium and low fruit/vegetables dietary intake and physical inactivity); (2) obesity; and (3) hypertension.

This study will address the following research questions: Are the observed racial differences in maladaptive health behaviors (diet/inactivity) and MetS components (obesity, hypertension) associated with: a) perceived psychosocial stress, and if so, does depression, neighborhood factors or health beliefs around weight and weight control modify this relationship?

Exclusion Criteria:

Sexes Eligible for Study: All
30 Years to 65 Years   (Adult)
Contact information is only displayed when the study is recruiting subjects
United States
1024-2004 ( Other Identifier: Other )
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Arshed A. Quyyumi, Emory University
Emory University
  • National Institutes of Health (NIH)
  • Morehouse School of Medicine
Principal Investigator: Arshed Quyyumi, MD Emory University
Principal Investigator: Gary Gibbons, MD Morehouse School of Medicine
Emory University
November 2013