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The Effects of a 16-Week Individualized, Intensive Strength Training Program in Patients With Rheumatoid Arthritis

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ClinicalTrials.gov Identifier: NCT00327275
Recruitment Status : Completed
First Posted : May 18, 2006
Last Update Posted : May 18, 2006
Centocor, Inc.
Information provided by:
University of Arizona

May 16, 2006
May 18, 2006
May 18, 2006
March 2004
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  • Strength
  • Body Composition
  • Function
  • Pain
Same as current
No Changes Posted
  • Quality of Life
  • Disease Activity
  • Fatigue
Same as current
Not Provided
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The Effects of a 16-Week Individualized, Intensive Strength Training Program in Patients With Rheumatoid Arthritis
The Strength Training and Remicade Study

To assess the effects of a 16-week individualized, intensive strength training program in patients with rheumatoid arthritis. Primary and secondary outcomes include: strength and body composition, function, disease activity, pain, quality of life.

We hypothesized that improvements would be seen in all of the above outcomes.

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Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Rheumatoid Arthritis
Behavioral: strength training
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
January 2005
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Inclusion Criteria:

  • Males and females with RA
  • Over 18 years of age
  • ACR Functional Class I and II
  • Taking Remicade >4 months

Exclusion Criteria:

  • Presence of comorbid conditions contraindicated to exercise, including, but not limited to:

    1. heart disease
    2. severe osteoporosis: (if >50 years): T score < -3.0 for hip or spine excluded; T score <-2.5 for hip or spine w/o current treatment)
    3. (all potential subjects) previous non-traumatic fractures
    4. uncontrolled BP
  • BMI >40
  • Regular use of assistive walking device which would interfere with ability to lift weights
  • Currently or within the last 3 months participating in aerobic exercise > 150 minutes a week
  • Currently or within the last 3 months participating in any regular strength training activities
  • Presence of neurological impairment that directly limits ability to perform exercise
  • Participation in concurrent exercise study
  • Any reason for which the investigator deems it would not be in the patient’s best interest to continue in the study
  • Plans to move away from site within next 1 year
Sexes Eligible for Study: All
18 Years and older   (Adult, Senior)
Contact information is only displayed when the study is recruiting subjects
United States
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University of Arizona
Centocor, Inc.
Principal Investigator: Hilary G Flint-Wagner, PhD, MPH Idaho State University
University of Arizona
May 2006

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP