A Clinical Trial Assessing the Impact of Inhaled Insulin on Glucose Disposition

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00287066
Recruitment Status : Terminated (See termination reason in detailed description.)
First Posted : February 6, 2006
Last Update Posted : February 21, 2008
Information provided by:

February 2, 2006
February 6, 2006
February 21, 2008
February 2006
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18F-labeled glucose uptake in muscle
Same as current
Complete list of historical versions of study NCT00287066 on Archive Site
Glucose turnover overnight Insulin pharmacokinetics
Same as current
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A Clinical Trial Assessing the Impact of Inhaled Insulin on Glucose Disposition
Open-Label Randomized Two-Way Crossover Pilot Study To Estimate The Effects Of Inhaled Versus IV Infusion Of Human Insulin With Regards To Glucose Disposal In Subjects With Type 1 Diabetes Mellitus
To assess the impact of inhalation of insulin on glucose disposition in patients with type 1 diabetes
The study was terminated on Oct. 28, 2007. The protocol was undergoing implementation and methodological issues with major revisions that qualified this trial as a new trial. Pfizer decided to cancel new trials because of the decision to withdraw Exubera due to lack of market performance and not for safety reasons.
Phase 3
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Diabetes Mellitus
  • Drug: Inhaled Human Insulin
  • Drug: Regular Human Insulin
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*   Includes publications given by the data provider as well as publications identified by Identifier (NCT Number) in Medline.
March 2007
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Inclusion Criteria:

  • Diabetes mellitus Type 1

Exclusion Criteria:

  • Asthma, COPD
  • Smoking
Sexes Eligible for Study: All
18 Years to 50 Years   (Adult)
Contact information is only displayed when the study is recruiting subjects
United States
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Study Director: Pfizer Call Center Pfizer
April 2007

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP