Genetics of Rolandic Epilepsy

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00282854
Recruitment Status : Unknown
Verified August 2011 by King's College London.
Recruitment status was:  Recruiting
First Posted : January 27, 2006
Last Update Posted : December 6, 2011
National Institute of Neurological Disorders and Stroke (NINDS)
Information provided by:
King's College London

January 26, 2006
January 27, 2006
December 6, 2011
January 2005
December 2013   (Final data collection date for primary outcome measure)
Not Provided
Not Provided
Complete list of historical versions of study NCT00282854 on Archive Site
Not Provided
Not Provided
Not Provided
Not Provided
Genetics of Rolandic Epilepsy
Genetics of Rolandic Epilepsy
The purpose of this study is to find the genes that cause Rolandic epilepsy and its related traits.

Rolandic epilepsy (RE) is the most common type of childhood epilepsy—affecting more than 50,000 children in the United States—and has a complex genetic inheritance. The seizure prognosis is relatively benign, however, many children with RE also have problems with speech and language, reading, and motor coordination. Symptoms of the disorder overlap with more severe types of epilepsy.

The purpose of this study is to find the genes that influence RE and its related traits. Identifying genetic causes for the variants would improve diagnosis and allow for early intervention.

Researchers will enroll 1000 children with RE and 3000 controls for participation in the study. The scientists will request medical histories and (salivary) DNA samples from the participants. Participation can be completed by mail and telephone.

Results from this study should provide important information regarding diagnosis and prognosis of RE, may be useful in clinical management, and, eventually, may lead to a cure for this and other forms of epilepsy.

Observational Model: Case Control
Time Perspective: Cross-Sectional
Not Provided
Retention:   Samples With DNA
whole blood
Non-Probability Sample
Community Sample
Not Provided
  • Group I: Cases
    Children with rolandic epilepsy
  • Group II: Controls
    Individuals group matched to cases for ethnicity, sex and area of residence but lacking a primary brain disorder.
Not Provided

*   Includes publications given by the data provider as well as publications identified by Identifier (NCT Number) in Medline.
Unknown status
December 2013
December 2013   (Final data collection date for primary outcome measure)


  • typical history of focal seizures
  • EEG centrotemporal sharp waves
  • age of onset 3-12 years
  • no previous epilepsy type (febrile seizures OK)
  • normal development
  • normal neurological examination
  • normal MRI/CT (if done)


  • only history of secondary generalized seizures
  • atypical history/semiology
  • history and EEG inconsistent
  • abnormal EEG background
  • very early (<3yrs) or late (>12yrs) onset
  • global neurodevelopmental deficit
  • deviant neurodevelopment
  • structural imaging abnormality
Sexes Eligible for Study: All
3 Years and older   (Child, Adult, Older Adult)
Contact information is only displayed when the study is recruiting subjects
United States
R01NS047530 ( U.S. NIH Grant/Contract )
Not Provided
Not Provided
Deb K Pal MD PHD, Columbia University
King's College London
National Institute of Neurological Disorders and Stroke (NINDS)
Principal Investigator: Deb K. Pal, MD, PhD Associate Research Scientist, Mailman School of Public Health, Columbia University Medical Center
King's College London
August 2011