Twins and the Risk of Parkinson's Disease: A Clinical and Imaging Study
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|ClinicalTrials.gov Identifier: NCT00282802|
Recruitment Status : Unknown
Verified July 2009 by The Parkinson's Institute.
Recruitment status was: Active, not recruiting
First Posted : January 27, 2006
Last Update Posted : July 2, 2009
|First Submitted Date||January 26, 2006|
|First Posted Date||January 27, 2006|
|Last Update Posted Date||July 2, 2009|
|Study Start Date||April 2001|
|Primary Completion Date||Not Provided|
|Current Primary Outcome Measures
||Onset of Parkinson's disease [ Time Frame: duration of the project ]|
|Original Primary Outcome Measures||Not Provided|
|Change History||Complete list of historical versions of study NCT00282802 on ClinicalTrials.gov Archive Site|
|Current Secondary Outcome Measures
||Age of Parkinson's disease onset [ Time Frame: duration of the project ]|
|Original Secondary Outcome Measures||Not Provided|
|Current Other Outcome Measures||Not Provided|
|Original Other Outcome Measures||Not Provided|
|Brief Title||Twins and the Risk of Parkinson's Disease: A Clinical and Imaging Study|
|Official Title||Twins and the Risk of PD: A Clinical and Imaging Study|
|Brief Summary||The purpose of this study is to examine the role of genetic and environmental factors in the cause of Parkinson's disease.|
Parkinson's disease (PD) is a growing health problem in the elderly, and genetic factors may provide substantial clues toward eventual treatment and/or prevention of the disorder. The National Academy of Sciences/National Resource Council (NAS/NRC) World War II (WWII) Veteran Twins Cohort Registry is one of the few population-based groups of elderly twins. Previous studies in this group indicated that genetic factors were involved only in early-onset PD, however there was no follow-up to these studies.
The purpose of the "Twins and the Risk of PD" study is to follow-up previous studies and confirm the initial findings. In this study, investigators will use the NAS/NRC WWII Veteran Twin Cohort Registry to compare the concordance rates for PD in monozygotic and dizygotic twins—at least one of whom has PD.
The overall goal of this research is determine the contributions of genetic and environmental factors in the cause of PD.
The study will involve traditional clinical research methods, such as a clinical examination, as well as innovative imaging techniques, such as single photon emission computed tomography (SPECT). SPECT—a nuclear imaging test involving blood flow to tissue—is used to evaluate certain brain functions.
Findings from this study may help to set research priorities in PD, and to develop tools for early detection of the disorder.
|Study Design||Observational Model: Cohort
Time Perspective: Prospective
|Target Follow-Up Duration||Not Provided|
|Sampling Method||Probability Sample|
|Study Population||Participants will be recruited from a closed cohort—the National Academy of Sciences/National Resource Council (NAS/NRC) World War II Veteran Twins Cohort|
National Academy of Sciences/National Resource Council (NAS/NRC) World War II Veteran Twins Cohort
|Publications *||Not Provided|
* Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
|Recruitment Status||Unknown status|
|Original Enrollment||Same as current|
|Estimated Study Completion Date||July 2010|
|Primary Completion Date||Not Provided|
|Ages||77 Years to 88 Years (Senior)|
|Accepts Healthy Volunteers||No|
|Contacts||Contact information is only displayed when the study is recruiting subjects|
|Listed Location Countries||United States|
|Removed Location Countries|
|Other Study ID Numbers||R01NS040467( U.S. NIH Grant/Contract )
R01NS040467-01 ( U.S. NIH Grant/Contract )
|Has Data Monitoring Committee||No|
|U.S. FDA-regulated Product||Not Provided|
|IPD Sharing Statement||Not Provided|
|Responsible Party||Caroline M. Tanner, MD, PhD, Director of Clinical Research, The Parkinson's Institute|
|Study Sponsor||The Parkinson's Institute|
|Collaborators||National Institute of Neurological Disorders and Stroke (NINDS)|
|PRS Account||The Parkinson's Institute|
|Verification Date||July 2009|