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Identification of Genomic Predictors of Adverse Events After Cardiac Surgery (CABGGenomics)

This study is currently recruiting participants.
Verified October 2017 by Simon Body, Brigham and Women's Hospital
Sponsor:
ClinicalTrials.gov Identifier:
NCT01258231
First Posted: December 10, 2010
Last Update Posted: October 4, 2017
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.
Collaborators:
National Heart, Lung, and Blood Institute (NHLBI)
Texas Heart Institute
University of Texas Southwestern Medical Center
Information provided by (Responsible Party):
Simon Body, Brigham and Women's Hospital
December 9, 2010
December 10, 2010
October 4, 2017
August 2000
August 2020   (Final data collection date for primary outcome measure)
  • Atrial fibrillation [ Time Frame: 30 days ]
    Atrial fibrillation
  • Death [ Time Frame: 5 years ]
    Death
  • Renal dysfunction [ Time Frame: 30 days ]
    Renal dysfunction
  • Atrial fibrillation
    Atrial fibrillation
  • Myocardial infarction
    Myocardial infarction
  • Heart failure
    Heart failure
Complete list of historical versions of study NCT01258231 on ClinicalTrials.gov Archive Site
Not Provided
Not Provided
Not Provided
Not Provided
 
Identification of Genomic Predictors of Adverse Events After Cardiac Surgery
Identification of Genomic Predictors of Adverse Events After Cardiac Surgery

This study aims to identify genetic causes of adverse events after cardiac surgery, such as atrial fibrillation, myocardial infarction, renal dysfunction and heart failure.

Patients undergoing heart surgery at Brigham and Women's Hospital and Texas Heart Institute are eligible to participate.

This study aims to identify genetic causes of adverse events after cardiac surgery, such as atrial fibrillation, myocardial infarction, renal dysfunction and heart failure.
Observational
Observational Model: Cohort
Time Perspective: Prospective
Not Provided
Retention:   Samples With DNA
Description:
DNA, buffy coat, plasma, serum and urine
Non-Probability Sample
Adult patients undergoing heart surgery
  • Heart; Dysfunction Postoperative, Cardiac Surgery
  • Genetic Predisposition to Disease
  • Atrial Fibrillation
  • Myocardial Infarction
  • Heart Failure
Not Provided
Cardiac surgery
Adult patients undergoing cardiac surgery

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
4000
August 2020
August 2020   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • Undergoing heart surgery
  • Willing to provide consent

Exclusion Criteria:

  • Enrolled in a concurrent drug or device trial that precludes concurrent enrollment
Sexes Eligible for Study: All
20 Years to 90 Years   (Adult, Senior)
No
United States
 
 
NCT01258231
2000P001639
5R01HL098601 ( U.S. NIH Grant/Contract )
No
Not Provided
Not Provided
Simon Body, Brigham and Women's Hospital
Brigham and Women's Hospital
  • National Heart, Lung, and Blood Institute (NHLBI)
  • Texas Heart Institute
  • University of Texas Southwestern Medical Center
Principal Investigator: Simon C Body, MBChB, MPH Brigham and Women's Hospital
Brigham and Women's Hospital
October 2017