Identification of Genomic Predictors of Adverse Events After Cardiac Surgery (CABGGenomics)

This study is currently recruiting participants. (see Contacts and Locations)
Verified July 2015 by Brigham and Women's Hospital
Sponsor:
Collaborators:
Texas Heart Institute
University of Texas Southwestern Medical Center
Information provided by (Responsible Party):
Simon Body, Brigham and Women's Hospital
ClinicalTrials.gov Identifier:
NCT01258231
First received: December 9, 2010
Last updated: July 14, 2015
Last verified: July 2015

December 9, 2010
July 14, 2015
August 2000
August 2020   (final data collection date for primary outcome measure)
  • Atrial fibrillation [ Time Frame: 30 days ] [ Designated as safety issue: No ]
    Atrial fibrillation
  • Death [ Time Frame: 5 years ] [ Designated as safety issue: No ]
    Death
  • Renal dysfunction [ Time Frame: 30 days ] [ Designated as safety issue: No ]
    Renal dysfunction
  • Atrial fibrillation [ Designated as safety issue: No ]
    Atrial fibrillation
  • Myocardial infarction [ Designated as safety issue: No ]
    Myocardial infarction
  • Heart failure [ Designated as safety issue: No ]
    Heart failure
Complete list of historical versions of study NCT01258231 on ClinicalTrials.gov Archive Site
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Identification of Genomic Predictors of Adverse Events After Cardiac Surgery
Identification of Genomic Predictors of Adverse Events After Cardiac Surgery

This study aims to identify genetic causes of adverse events after cardiac surgery, such as atrial fibrillation, myocardial infarction, renal dysfunction and heart failure.

Patients undergoing heart surgery at Brigham and Women's Hospital and Texas Heart Institute are eligible to participate.

This study aims to identify genetic causes of adverse events after cardiac surgery, such as atrial fibrillation, myocardial infarction, renal dysfunction and heart failure.

Observational
Observational Model: Cohort
Time Perspective: Prospective
Not Provided
Retention:   Samples With DNA
Description:

DNA, buffy coat, plasma and serun

Non-Probability Sample

Adult patients undergoing heart surgery

  • Heart; Dysfunction Postoperative, Cardiac Surgery
  • Genetic Predisposition to Disease
  • Atrial Fibrillation
  • Myocardial Infarction
  • Heart Failure
Not Provided
Cardiac surgery
Adult patients undergoing cardiac surgery
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Recruiting
4000
August 2020
August 2020   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • Undergoing heart surgery
  • Willing to provide consent

Exclusion Criteria:

  • Enrolled in a concurrent drug or device trial that precludes concurrent enrollment
Both
20 Years to 90 Years
No
United States
 
NCT01258231
2000P001639, 5R01HL098601
No
Simon Body, Brigham and Women's Hospital
Brigham and Women's Hospital
  • National Heart, Lung, and Blood Institute (NHLBI)
  • Texas Heart Institute
  • University of Texas Southwestern Medical Center
Principal Investigator: Simon C Body, MBChB, MPH Brigham and Women's Hospital
Brigham and Women's Hospital
July 2015

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP