Nonalcoholic Fatty Liver Disease in Taiwanese Children

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details. Identifier: NCT00274183
Recruitment Status : Recruiting
First Posted : January 10, 2006
Last Update Posted : March 30, 2017
Information provided by (Responsible Party):
Far Eastern Memorial Hospital

January 2, 2006
January 10, 2006
March 30, 2017
January 2006
December 2017   (Final data collection date for primary outcome measure)
non-alcoholic fatty liver disease confirmed by liver ultrasonography [ Time Frame: one year ]
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Complete list of historical versions of study NCT00274183 on Archive Site
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Nonalcoholic Fatty Liver Disease in Taiwanese Children
Prevalence, Clinicopathological Characteristics, Biomarkers and Genetics of Nonalcoholic Steatohepatitis in Taiwanese Children
Nonalcoholic fatty liver disease (NAFLD) is an emerging and important disease in Taiwan. However, the prevalence and clinical characteristics have not been studied well. The purpose of this study is to resolve the aforementioned problem.

[Study Subjects] Obesity was defined as the BMI value > 95 percentile by different age- and gender groups according to the standards of the Department of Health in Taiwan.

[Data Collection] The following data were obtained for each subject: age, gender, BMI, waist and hip circumference. BMI was calculated as body weight (kg)/ height (m2).

In fasting venous blood samples, we measured total serum bilirubin, alanine aminotransferase, aspartate aminotransferase, γ-glutamyltransferase, fasting glucose, triglyceride, total cholesterol,high-density lipoprotein cholesterol, insulin, glucose, and adiponectin.

[Liver Ultrasonography] All participants underwent an ultrasonographic study of the liver performed by one operator.

NAFLD was defined as the presence of an ultrasonographic pattern consistent with the following criteria: liver-kidney echo discrepancy, attenuated echo penetration and visibility of diaphragm, and obscure hepatic vessel structures.

Observational Model: Cohort
Time Perspective: Prospective
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Retention:   Samples With DNA
Serum, WBC DNA
Probability Sample
Obese children will be enrolled from elementary school and high school in Taiwan
Fatty Liver
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*   Includes publications given by the data provider as well as publications identified by Identifier (NCT Number) in Medline.
December 2019
December 2017   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • diagnosis of fatty liver

Exclusion Criteria:

  • other hepatic diseases
Sexes Eligible for Study: All
6 Years to 18 Years   (Child, Adult)
Contact: Yu-Cheng Lin, M.D. 886-2-89667000 ext 4449
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Plan to Share IPD: Undecided
Far Eastern Memorial Hospital
Far Eastern Memorial Hospital
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Principal Investigator: Yu-Cheng Lin, M.D. Far Eastern Memorial Hospital
Far Eastern Memorial Hospital
March 2017