Outcome of Crisis Intervention for Subjects With Borderline Personality Disorder or Post-Traumatic Stress Disorder

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00269139
Recruitment Status : Unknown
Verified December 2005 by Laddis, Andreas, M.D..
Recruitment status was:  Not yet recruiting
First Posted : December 23, 2005
Last Update Posted : February 20, 2006
Information provided by:
Laddis, Andreas, M.D.

December 21, 2005
December 23, 2005
February 20, 2006
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  • Brief Psychiatric Rating Scale (BPRS) scores
  • Scores on Client Observation and Client Interview, tools designed for this study
  • BPRS scores
  • Scores with Client Observation and Client Interview, tools designed for this study
Complete list of historical versions of study NCT00269139 on Archive Site
  • Patient interview and ratings for the value of the clinicians' interventions
  • Staff interview and ratings for their own interventions
Same as current
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Outcome of Crisis Intervention for Subjects With Borderline Personality Disorder or Post-Traumatic Stress Disorder
Study of Outcome With an Intervention From the Cape Cod Model of Psychotherapy for Subjects in a Behavioral Crisis and With the Diagnosis of Borderline Personality Disorder (BPD) or Post-Traumatic Stress Disorder (PTSD)

Dr. Laddis will test a hypothesis about the nature and the management of behavioral crises in patients with borderline personality disorder (BPD) or post-traumatic stress disorder (PTSD). The term "behavioral crisis" is used strictly for periods of uncontrollable urges to repeat mental or outward activity, e.g., flashbacks, cutting, binging on food, drugs or sex, with no intervals to rethink one's priorities or to consider others' direction.

The clinical hypothesis states, in two steps, that:

  1. the perception of a life crisis precedes and then underlies every behavioral crisis;
  2. the behavioral crisis resolves promptly and all symptoms end if the clinicians engage the patient about his management of the life crisis that underlies the symptoms.

Subjects in the experimental group will be treated by Dr. Laddis after their admission to a crisis stabilization unit (CSU) or to an inpatient unit (IPU) for a behavioral crisis. Subjects will be included at random, as assigned to Dr. Laddis according to his routine duties at those units.

Subjects in the control group will receive treatment for behavioral crisis according to the preference of the clinical staff at other comparable units. That treatment will constitute "treatment as usual". Clinicians in the control settings will not be informed about the experimental hypothesis, the clinical intervention and the contingent outcomes.

The subjects will be tested for the results of treatment 12-24 hours after composition of a treatment plan. The testing will be done with the Brief Psychiatric Rating Scale (BPRS), as well as with a set of criteria devised by Dr. Laddis to measure the outward behavior and the mental events during behavioral crisis. The patients and the attending frontline staff will be interviewed also about their beliefs in regard to what, among the clinicians' interventions, made a difference for the course of the behavioral crisis, for better or for worse. The raters will be trained for interrater reliability and they will not be informed about the hypothesis.

Phase 1
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
  • Borderline Personality Disorder
  • Post-Traumatic Stress Disorders
Behavioral: Crisis resolution
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Laddis A. Outcome of crisis intervention for borderline personality disorder and post traumatic stress disorder: a model for modification of the mechanism of disorder in complex post traumatic syndromes. Ann Gen Psychiatry. 2010 Apr 27;9:19. doi: 10.1186/1744-859X-9-19.

*   Includes publications given by the data provider as well as publications identified by Identifier (NCT Number) in Medline.
Unknown status
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Inclusion Criteria:

  • Diagnosed with BPD or PTSD, with a structured interview according to the current diagnostic manual
  • In behavioral crisis

Exclusion Criteria:

  • Brain damage
  • Currently intoxicated with alcohol or drugs or in withdrawal
Sexes Eligible for Study: All
19 Years to 65 Years   (Adult)
Contact information is only displayed when the study is recruiting subjects
United States
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Laddis, Andreas, M.D.
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Principal Investigator: Andreas Laddis, MD Cape Cod and Islands Community Mental Health Center
Laddis, Andreas, M.D.
December 2005

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP