We are updating the design of this site. Learn more.
Show more
ClinicalTrials.gov
ClinicalTrials.gov Menu

Resynchronization of Left Ventricular Contraction After Reimplantation of Anomalous Left Coronary Artery

This study has been terminated.
(sufficient data collected for analysis)
Sponsor:
ClinicalTrials.gov Identifier:
NCT00268112
First Posted: December 22, 2005
Last Update Posted: March 16, 2012
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Children's Healthcare of Atlanta
December 20, 2005
December 22, 2005
March 16, 2012
January 2004
Not Provided
Not Provided
Not Provided
Complete list of historical versions of study NCT00268112 on ClinicalTrials.gov Archive Site
Not Provided
Not Provided
Not Provided
Not Provided
 
Resynchronization of Left Ventricular Contraction After Reimplantation of Anomalous Left Coronary Artery
Resynchronization of Left Ventricular Contraction After Re-implantation of Anomalous Left Coronary Artery From the Pulmonary Artery (ALCAPA) Evaluated by Tissue Doppler Imaging

Spontaneous resynchronization of dyskinetic segments of the left ventricle occurs after coronary bypass surgery in adults and has been shown in some children. It is, however, unknown what degree of dyskinesis is likely to be reversible in infants with ischemia from anomalous coronary arteries and what criteria would indicate that a resynchronization strategy of biventricular pacing might be needed.

These questions need data from quantitative serial tissue Doppler observations of patients from pre-operative to late post-operative follow-up.

We have previously studied, at Children's Healthcare of Atlanta, Egleston Hospital, 2 patients with ALCAPA and one other patient is currently enrolled in a prospective study after recent surgery, also at Children's Healthcare of Atlanta. We propose to study these 3 patients with this rare defect concurrently with their routine echocardiographic evaluations. Data will then be taken off-line for analysis.

Standard deviations of times to peak contraction velocity will be assessed for twelve cardiac segments. These will be reevaluated at follow up intervals after surgery on previously obtained echocardiograms. Those subjects in whom improvement of cardiac function, Left Ventricular Ejection Fraction (LVEF) and mitral regurgitation is seen will be compared to those in whom no improvement occurs.

Observational
Time Perspective: Retrospective
Not Provided
Not Provided
Non-Probability Sample
Cardiac pediatric patients
Congenital Disorders
Not Provided
Not Provided
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Terminated
3
December 2006
Not Provided

Inclusion Criteria:

  • Re-implantation of an anomalous left coronary artery from the pulmonary artery

Exclusion Criteria:

  • those patients who do not meet inclusion criteria
Sexes Eligible for Study: All
up to 21 Years   (Child, Adult)
No
Contact information is only displayed when the study is recruiting subjects
United States
 
 
NCT00268112
05-203
No
Not Provided
Not Provided
Not Provided
Children's Healthcare of Atlanta
Not Provided
Principal Investigator: Derek A. Fyfe, MD, PhD Sibley Heart Center Cardiology at Children's Healthcare of Atlanta
Children's Healthcare of Atlanta
December 2006