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Brain Aging Project--Kansas University

This study has been completed.
Sponsor:
Collaborators:
University of Kansas
National Institute on Aging (NIA)
Information provided by (Responsible Party):
University of Kansas Medical Center
ClinicalTrials.gov Identifier:
NCT00267124
First received: December 16, 2005
Last updated: April 4, 2017
Last verified: April 2017

December 16, 2005
April 4, 2017
November 2004
August 2009   (Final data collection date for primary outcome measure)
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Complete list of historical versions of study NCT00267124 on ClinicalTrials.gov Archive Site
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Brain Aging Project--Kansas University
KU Brain Aging Project
The purpose of this study is to determine the effects of exercise and cardiorespiratory fitness on age-related brain changes.

The mission of the KU Brain Aging Project is to promote healthy brain aging. How the brain changes with age is not well-characterized and even less is known about the factors influencing the rate of brain aging. Thus, we are using MRI scans to examine the structure of the brain in relation to important lifestyle factors. This will allow us to better understand the processes influencing the brain as it ages. In turn, this will help identify specific ways to promote healthy brain aging and, perhaps, prevent the onset of Alzheimer's disease.

Participants complete 4 visits over several months. The first visit entails a clinical evaluation and memory testing involving the use of paper and pencil testing. The second visit is an MRI brain scan which lasts approximately one hour. The third visit involves drawing blood for laboratory testing and blood banking for future lab studies, lasting roughly 4 hours. The glucose tolerance test is administered. The fourth and final visit is an assessment of the participant's metabolism and exercise testing. This visit lasts approximately two hours.

Observational
Observational Model: Case-Control
Time Perspective: Prospective
Not Provided
Retention:   Samples With DNA
Description:
Blood samples are collected analyzed and banked as whole blood, serum, white blood cells
Non-Probability Sample
KU memory clinic patients, volunteers from the community, and the states of Kansas and Missouri
Alzheimer's Disease
Not Provided
  • 1
    elderly people who have normal cognition
  • 2
    elderly people who have mild to moderate Alzheimer's disease
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
172
August 2009
August 2009   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • Age 65 years or older
  • Healthy male or female
  • Normal control volunteers and early Alzheimer's disease patients
  • Clinical Dementia Rating of 0, 0.5, or 1.0
  • On stable doses of medications

Exclusion Criteria:

  • Unstable angina
  • Schizophrenia
  • Clinical signs of depression; major depression; mental health disorder; nervous system disorder
  • Significant visual/auditory impairment
  • Significant system illness; cancer
  • Pacemaker/metal
  • Thyroid problems
  • Kidney dialysis
  • Organ transplant
  • Alcoholism
  • Heart surgery
  • Insulin
Sexes Eligible for Study: All
65 Years and older   (Adult, Senior)
Yes
Contact information is only displayed when the study is recruiting subjects
United States
 
 
NCT00267124
IA0089
1R03AG026374-01 ( US NIH Grant/Contract Award Number )
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University of Kansas Medical Center
University of Kansas Medical Center
  • University of Kansas
  • National Institute on Aging (NIA)
Principal Investigator: Jeffrey Burns, MD University of Kansas Medical Center, Landon Center on Aging
University of Kansas Medical Center
April 2017

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP