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Microvascular Reactivity.

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00259701
First Posted: November 29, 2005
Last Update Posted: October 6, 2006
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Yale University
November 28, 2005
November 29, 2005
October 6, 2006
June 2005
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Complete list of historical versions of study NCT00259701 on ClinicalTrials.gov Archive Site
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Microvascular Reactivity.
Transdermal Application of Acetylcholine and Nitroglycerin Without Iontophoresis.
This study attempts to test capillary responses to various challenges without the need for iontophoresis (electrical current).
Studies of microvascular responsiveness often employ iontophoresis to fascilitate drug absorption. Iontophoresis is a confounding stimulus in such studies, and we are attempting to create tests of the microvasculature that do not require iontophoretic drug delivery.
Observational
Observational Model: Defined Population
Primary Purpose: Screening
Time Perspective: Cross-Sectional
Time Perspective: Prospective
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  • Diabetes
  • Retinopathy
  • Vascular Pathology
Device: Laser Doppler Flowmetry with topical acetylcholine and nitroglycerin
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Schonberger RB, Worden WS, Shahmohammadi K, Menn K, Silverman TJ, Stout RG, Shelley KH, Silverman DG. Topical non-iontophoretic application of acetylcholine and nitroglycerin via a translucent patch: a new means for assessing microvascular reactivity. Yale J Biol Med. 2006 Mar;79(1):1-7.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
20
September 2005
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Inclusion Criteria: diabetic. -

Exclusion Criteria: not on nitrates or mydriatic eye drops within 48 hours.

Sexes Eligible for Study: All
18 Years and older   (Adult, Senior)
Yes
Contact information is only displayed when the study is recruiting subjects
United States
 
 
NCT00259701
HIC-12397-1
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Yale University
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Principal Investigator: David G Silverman Yale School of Medicine
Yale University
November 2005