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Employment-based Reinforcement to Motivate Drug Abstinence in the Treatment of Drug Addiction. - 1

This study has been completed.
Sponsor:
Collaborators:
National Institute on Drug Abuse (NIDA)
Johns Hopkins University
Information provided by (Responsible Party):
Kenneth Silverman, Johns Hopkins University
ClinicalTrials.gov Identifier:
NCT00249496
First received: November 3, 2005
Last updated: October 25, 2016
Last verified: October 2016

November 3, 2005
October 25, 2016
October 2003
August 2007   (Final data collection date for primary outcome measure)
Percentage of Monthly Urine Samples That Are Negative for Cocaine [ Time Frame: 1 year ]
The percentage of urine samples collected at monthly assessments that are negative for cocaine.
Percentage of urine samples at the 30-day assessments that are negative for cocaine
Complete list of historical versions of study NCT00249496 on ClinicalTrials.gov Archive Site
Not Provided
  • HIV risk behaviors
  • Percentage of 30-day assessment urine samples negative for opiates
  • Percentage of 30-day assessments that subjects report complete opiate abstinence
Not Provided
Not Provided
 
Employment-based Reinforcement to Motivate Drug Abstinence in the Treatment of Drug Addiction. - 1
Therapeutic Workplace Maintenance Study
This application is a competing continuation of a grant in which we developed and pilot tested a computerized Therapeutic Workplace designed to train and employ adults as data entry operators. A randomized trial is planned over 5 years to investigate the Therapeutic Workplace business as a maintenance intervention to sustain long-term abstinence and employment. Welfare recipients in methadone treatment, actively using cocaine, and at risk for contracting or spreading HIV infection will participate in an initial Therapeutic Workplace training phase. Participants (N=104) who become abstinent and skilled will be randomly assigned to an Abstinence & Employment, or an Employment Only group. Participants in the Abstinence & Employment group will be employed for one year in a Therapeutic Workplace business and will have to provide drug-free urine samples to work and earn salary. Employment Only participants will be offered employment for one year, but these participants will not have to provide drug-free urine samples to work. This study will provide a rigorous evaluation of the efficacy of the Therapeutic Workplace business as a long-term treatment of cocaine addiction and unemployment; determine the benefits of requiring daily evidence of abstinence to work; and provide information on the extent to which a Therapeutic Workplace business can become self-sustaining. This research could provide firm scientific foundation for the dissemination of Therapeutic Workplace businesses in the long-term treatment of cocaine addiction and unemployment. The main hypothesis being tested is that cocaine abstinence will be reliably maintained during the yearlong intervention evaluation period only in the group exposed to the explicit abstinence maintenance intervention. We expect that cocaine abstinence in the Abstinence and Employment group will be significantly greater than cocaine abstinence in the Employment Only group.
Not Provided
Interventional
Not Provided
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
  • Alcohol Use
  • Drug Use
  • Risk Behavior
  • Sexual Behavior
  • Behavioral: Contingency management
    Participants in the Contingency Management group will be employed for one year in a Therapeutic Workplace business and will have to provide drug-free urine samples to work and earn salary.
  • Behavioral: Employment Only
    Employment Only participants will be offered employment for one year, but these participants will not have to provide drug-free urine samples to work.
  • Active Comparator: Employment Only
    Employment Only participants will be offered employment for one year, but these participants will not have to provide drug-free urine samples to work.
    Intervention: Behavioral: Employment Only
  • Experimental: Contingency Management
    Participants in the Contingency Management group will be employed for one year in a Therapeutic Workplace business and will have to provide drug-free urine samples to work and earn salary.
    Intervention: Behavioral: Contingency management

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
128
August 2007
August 2007   (Final data collection date for primary outcome measure)

Inclusion Criteria:

  • Applicants in methadone treatment may be eligible to participate in Phase 1 of the study.
  • Applicants will be blind to the full details of the eligibility criteria.
  • Unemployed
  • Provided a urine sample at intake with a detectable concentration of cocaine metabolite or provided a cocaine positive sample during regular urinalysis testing at a methadone maintenance program
  • Met DSM-IV criteria for cocaine dependence
  • Were receiving welfare benefits in Baltimore, MD
  • Received a score of less than or equal to 80% correct on a reading assessment

Exclusion Criteria

  • Being at imminent risk for suicide
  • Reported hallucinations
  • Being incarcerated or otherwise under constant monitoring
  • Earned less than or equal to $200 in unreported taxable income from legal activity in the previous month
  • Having physical limitations that prevented typing
Sexes Eligible for Study: All
18 Years and older   (Adult, Senior)
No
Contact information is only displayed when the study is recruiting subjects
United States
 
 
NCT00249496
NIDA-13107-1
R01DA013107-01 ( US NIH Grant/Contract Award Number )
R01-13107-1
No
Not Provided
No
The results were published in a peer-reviewed journal.
Kenneth Silverman, Johns Hopkins University
Kenneth Silverman
  • National Institute on Drug Abuse (NIDA)
  • Johns Hopkins University
Principal Investigator: Kenneth Silverman, Ph.D. Johns Hopkins University
Johns Hopkins University
October 2016

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP