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Baltimore Longitudinal Study of Aging

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details. Identifier: NCT00233272
Recruitment Status : Recruiting
First Posted : October 5, 2005
Last Update Posted : April 3, 2019
Information provided by (Responsible Party):
National Institutes of Health Clinical Center (CC) ( National Institute on Aging (NIA) )

Tracking Information
First Submitted Date October 3, 2005
First Posted Date October 5, 2005
Last Update Posted Date April 3, 2019
Study Start Date January 21, 2003
Primary Completion Date Not Provided
Current Primary Outcome Measures
 (submitted: December 28, 2018)
The major aim of the BSLA is to characterize the aging process in its multifaceted aspects. [ Time Frame: Ongoing ]
Characterization of the aging process
Original Primary Outcome Measures Not Provided
Change History Complete list of historical versions of study NCT00233272 on Archive Site
Current Secondary Outcome Measures
 (submitted: December 24, 2014)
Describe longitudinal physical and cognitive changes that define aging. [ Time Frame: Ongoing ]
Original Secondary Outcome Measures Not Provided
Current Other Pre-specified Outcome Measures Not Provided
Original Other Pre-specified Outcome Measures Not Provided
Descriptive Information
Brief Title Baltimore Longitudinal Study of Aging
Official Title The Baltimore Longitudinal Syudy of Aging (BLSA)
Brief Summary


- The Baltimore Longitudinal Study of Aging (BLSA) is a clinical research program on human aging that began in 1958. Volunteers of different ages join the study when they are healthy, and have follow-up visits for life. Visits last for multiple days. Participants are evaluated for many physical elements as well as for brain function. Physical tests are given. Information on mood, personality, and social aspects of life is also collected. This program has contributed more than any other research project to our understanding of aging.


- To characterize the many aspects of the aging process and learn how people can successfully adapt to aging.


- Healthy individuals at least 20 years old.


  • Participants will receive a booklet and video describing the tests they will take.
  • During a 3-day visit at the study hospital, participants will take the following tests:
  • Urine will be collected for 24 hours. Blood samples will be taken. A small piece of muscle tissue may be collected by a needle.
  • A medical questionnaire and a physical exam will be given.
  • Participants hearts will be tested, including with blood pressure tests and electronic monitors. They will breathe into a tube to test their lungs.
  • Participants will perform several exercises, including treadmill walking.
  • Vision, hearing, and taste will be tested.
  • Bone and joint X-rays may be taken.
  • Imaging tests will be given, such as an MRI.
  • Participants will answer questions to test their mental abilities.
  • Participants will return for follow-up visits every few years for life. The tests listed above will be given at every visit.
Detailed Description The Baltimore Longitudinal Study of Aging (BLSA) is the NIA s major clinical research program in human aging that has been conducted in Baltimore since 1958. The study population is a series of healthy volunteers of different ages followed indefinitely with serial evaluations over time. The major aim of the study is to characterize the aging process in its multifaceted aspects. To accomplish this task, a large cohort of volunteers dispersed over a wide age range are enrolled in the study when they are healthy, and then followed with regular follow-up visits for life. Since the aging process involves the whole range of physiological domains, participants receive an extensive evaluation of physiological parameters, biomarkers, risk factors, disease-related measures, impairments, and physical and cognitive function over follow-up visits that last for multiple days. Blood samples and other specimens are collected to obtain part of these measures and/or to be stored for future use. Information on mood, personality, psychological and social aspects of life that are relevant to the study of aging is also collected. Information collected in the BLSA represents a unique source of longitudinal data on aging. Historically the BLSA has contributed more than any other research project to our understanding of aging. More recently, the BLSA has begun to focus on factors associated with exceptionally healthy aging.
Study Type Observational
Study Design Observational Model: Cohort
Time Perspective: Prospective
Target Follow-Up Duration Not Provided
Biospecimen Not Provided
Sampling Method Probability Sample
Study Population Healthy volunteers 20 years of age or older.
Condition Aging
Intervention Not Provided
Study Groups/Cohorts Healthy Volunteers
Healthy volunteers over a wide age-range
Publications *

*   Includes publications given by the data provider as well as publications identified by Identifier (NCT Number) in Medline.
Recruitment Information
Recruitment Status Recruiting
Estimated Enrollment
 (submitted: February 4, 2014)
Original Enrollment
 (submitted: October 3, 2005)
Study Completion Date Not Provided
Primary Completion Date Not Provided
Eligibility Criteria
  • Age greater than or equal to 20 years of age
  • Weigh less than or equal to 300lbs and/or body mass index (BMI) is less than or equal to 40
  • Do not have established genetic diseases
  • Are able to perform daily self- care without assistance
  • Are able to walk independently for at least 400 meters without assistance and without developing symptoms
  • Are able to perform normal activities of daily living without shortness of breath (walking or climbing stairs)
  • Do not have substantial cognitive impairment based on mental status screening tests
  • Do not have a history of cardiovascular disease (including angina, myocardial infarction, congestive heart failure, cerebrovascular diseases, uncontrolled hypertension)
  • Do not have a history of diabetes (requiring any medical treatment other than diet and exercise)
  • Do not have active (any activity in the last 10 years) cancer, except for locally limited basal cell cancer
  • Do not have clinically significant hormonal dysfunction (Laboratory values out of range despite supplementation and/or drug treatment)
  • Do not have a history of neurological diseases or birth defects (other than minor anatomical abnormalities, which do not affect physical and/or cognitive function)
  • Do not have a history of kidney or liver disease (associated with reduced kidney or liver function)
  • Do not have a history of severe gastrointestinal (G.I.) diseases
  • Do not have muscle-skeletal conditions due to diseases or traumas (that cause pathological weakness and/or chronic pain)
  • Do not have a history of severe psychiatric conditions (associated with behavioral problems or requiring chronic medical treatment)
  • Do not have any medical condition that requires absolute and continuous need for long term treatment with antibiotics, corticosteroids, immunosuppressors, H2 blockers and/or proton pump inhibitors, or pain medications
  • Do not have important sensory deficits (legally blind and/or any condition that precludes the participant from being tested with standard neuropsychological tests or providing informed consent)
  • Able to read and speak English
  • Do not have joint replacements due to arthritic changes (joint replacements due to previous trauma are ok) or do not have 2 or more joint replacements for any reason.
  • Do not meet any exclusionary criteria for MRI and agrees to perform the test


  • HIV virus infection
  • Hepatitis B or C
  • Syphilis
  • WBC > 12,000/mcrL;
  • Platelets < 100,000 or >600,000 /mcrL;
  • Hemoglobin < 11 g/dL;
  • Creatinine >1.5 mg/dl or calculated creatinine clearance < 50 cc/min;
  • Bilirubin > 1.5 mg/dl unless higher levels can be ascribed to Gilbert s disease;
  • ALT, AST or alkaline phosphatase twice the normal serum concentration
  • Corrected calcium < 8.5 or > 10.7 mg/dl
  • Albumin < 3.14 g/dl
Sexes Eligible for Study: All
Ages 20 Years to 110 Years   (Adult, Older Adult)
Accepts Healthy Volunteers Yes
Contact: Linda M Zukley, Ph.D. (410) 350-3983
Contact: Luigi Ferrucci, M.D. (410) 558-8110
Listed Location Countries United States
Removed Location Countries  
Administrative Information
NCT Number NCT00233272
Other Study ID Numbers 030325
Has Data Monitoring Committee Not Provided
U.S. FDA-regulated Product Not Provided
IPD Sharing Statement Not Provided
Responsible Party National Institutes of Health Clinical Center (CC) ( National Institute on Aging (NIA) )
Study Sponsor National Institute on Aging (NIA)
Collaborators Not Provided
Principal Investigator: Luigi Ferrucci, M.D. National Institute on Aging (NIA)
PRS Account National Institutes of Health Clinical Center (CC)
Verification Date March 26, 2019