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Treatment of Mild and Subthreshold Depressive Disorders

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified February 2002 by Ludwig-Maximilians - University of Munich.
Recruitment status was:  Active, not recruiting
ClinicalTrials.gov Identifier:
First Posted: September 27, 2005
Last Update Posted: December 9, 2005
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Ludwig-Maximilians - University of Munich
September 23, 2005
September 27, 2005
December 9, 2005
Not Provided
Not Provided
  • HAMD (changes between baseline and individual endpoint)
  • IDS (changes between baseline and individual endpoint)
Same as current
No Changes Posted
  • BDI (changes between baseline and individual endpoint)
  • CGI (changes between baseline and individual endpoint)
Same as current
Not Provided
Not Provided
Treatment of Mild and Subthreshold Depressive Disorders
Behandlung Von Leichten Und Unterschwelligen Depressionen. Eine Randomisierte, Kontrollierte Studie Zum Wirksamkeitsnachweis Eines Serotonin-Wiederaufnahme-Hemmers (SSRI), Einer Kognitiven Verhaltenstherapie Und Einer Freien Therapiewahl ("Treatment of Mild and Subthreshold Depressive Disorders". A Randomized, Controlled Trial on the Efficacy of a Serotonin-Reuptake-Inhibitor (SSRI), a Cognitive-Behavioral Therapy and of Free Choice Between SSRI and CBT")

The purpose of this study is to determine the efficacy of a SSRI, cognitive-bahavioral-therapy and a free choice between SSRI and CBT in a sample of primary care patients suffering from mild to moderate depression.


  • SSRI is superior to placebo
  • CBT is superior to a non-specific supporting group therapy
Not Provided
Phase 4
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double
Primary Purpose: Treatment
  • Drug: Sertralin
  • Behavioral: Cognitive-behavioral therapy
  • Drug: Placebo
  • Behavioral: Non-specific supporting group therapy
Not Provided

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
Unknown status
Not Provided
Not Provided

Inclusion Criteria:(e.g.)

  • subthreshold and mild depressive disorders including dysthymia (HAMD: 8-22)
  • informed consent
  • 18 years

Exclusion Criteria:(e.g.)

  • severe mood disorders
  • bipolar disorder
  • recurrent brief depression
  • suicidality
  • alcohol or drug dependency
  • obsessive-compulsive disorder
  • schizoaffective disorder / schizophrenia
  • pregnancy
Sexes Eligible for Study: All
18 Years and older   (Adult, Senior)
Contact information is only displayed when the study is recruiting subjects
Not Provided
Not Provided
Not Provided
Not Provided
Ludwig-Maximilians - University of Munich
Not Provided
Principal Investigator: Ulrich Hegerl, Prof, MD LMU, Department of Psychiatry
Ludwig-Maximilians - University of Munich
February 2002

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP