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KETOR: Effects of Peri Operative Administration of Ketamine on Long Term Post Thoracotomy Pain

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00224588
First Posted: September 23, 2005
Last Update Posted: April 13, 2006
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborators:
Direction Régionale de la Recherche Clinique D'ILE DE FRANCE
Clinical Research Unit
European Georges Pompidou Hospital
Information provided by:
Assistance Publique - Hôpitaux de Paris
September 16, 2005
September 23, 2005
April 13, 2006
January 2003
Not Provided
Long term (2 months) post thoracotomy pain was assessed using a french equivalent of the Mc Gill Pain score and pain area measurements in both groups
Same as current
Complete list of historical versions of study NCT00224588 on ClinicalTrials.gov Archive Site
Analogic pain scores at rest and after coughing
Same as current
Not Provided
Not Provided
 
KETOR: Effects of Peri Operative Administration of Ketamine on Long Term Post Thoracotomy Pain
Effects of Peri Operative Administration of Ketamine on Long Term Post Thoracotomy Pain
We assessed the effects of the N Methyl aspartate receptor antagonist Ketamine on long-term post thoracotomy pain. We hypothesized that ketamine could prevent supersensitization of the central nervous system involved in this chronic neuropathic pain.
In this clinical, randomized prospective study, peri operative administration of ketamine was compared to placebo on long term post thoracotomy pain after a 2 months follow up period.
Interventional
Phase 3
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double
Primary Purpose: Treatment
  • Ketamine
  • Chronic Post Thoracotomy Pain
  • Thoracotomy
  • Pain
  • Neuralgia
Drug: Ketamine (or placebo : isotonic saline solution)
Not Provided
Frappier J, Guenoun T, Journois D, Philippe H, Aka E, Cadi P, Silleran-Chassany J, Safran D. Airway management using the intubating laryngeal mask airway for the morbidly obese patient. Anesth Analg. 2003 May;96(5):1510-5, table of contents.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
80
May 2005
Not Provided

Inclusion Criteria:

  • Patients eligible for thoracotomy or pneumectomy

Exclusion Criteria:

Sexes Eligible for Study: All
80 Years and older   (Senior)
No
Contact information is only displayed when the study is recruiting subjects
France
 
 
NCT00224588
P990911
CRC99029
Not Provided
Not Provided
Not Provided
Not Provided
Assistance Publique - Hôpitaux de Paris
  • Direction Régionale de la Recherche Clinique D'ILE DE FRANCE
  • Clinical Research Unit
  • European Georges Pompidou Hospital
Principal Investigator: Thierry GUENOUN, MD Assistance Publique - Hôpitaux de Paris
Assistance Publique - Hôpitaux de Paris
September 2005

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP