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Molecular Genetic Screening and Identification of Congenital Arrhythmogenic Diseases

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ClinicalTrials.gov Identifier: NCT00221832
Recruitment Status : Unknown
Verified October 2003 by Heidelberg University.
Recruitment status was:  Recruiting
First Posted : September 22, 2005
Last Update Posted : January 13, 2010
Sponsor:
Information provided by:
Heidelberg University

September 14, 2005
September 22, 2005
January 13, 2010
October 2003
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Complete list of historical versions of study NCT00221832 on ClinicalTrials.gov Archive Site
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Molecular Genetic Screening and Identification of Congenital Arrhythmogenic Diseases
Molecular Genetic Screening and Identification of Congenital Arrhythmogenic Diseases
The aim of this study is the identification of familial congenital arrhythmogenic disorders and their clinical follow-up.

Molecular genetic screening in patients with:

  • supraventricular
  • ventricular arrhythmia
  • syncopes of unknown origin and/or suspicion of an arrhythmogenic origin
  • family members of patients with sudden cardiac death and aborted sudden cardiac death

Examination of patients includes routine testing like electrocardiogram (ECG), sequential ECGs, exercise testing, invasive electrophysiological stimulation, cardiac magnetic resonance imaging, intravenous drug challenge for identification/exclusion of eg Brugada syndrome. Examples are patients with Long QT Syndrome, Short QT Syndrome, Brugada Syndrome, familial atrial fibrillation, WPW-syndrome, arrhythmias due to familial hypertrophic cardiomyopathy or arrhythmogenic right ventricular dysplasia. Blood samples are taken for further molecular genetic screening.

Observational
Observational Model: Family-Based
Time Perspective: Prospective
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Retention:   Samples With DNA
Description:
no biospecimens are to be retained.
Non-Probability Sample
Consecutive patient sampling with history of syncope, aborted SCD, familial sudden cardiac death, high suspicion of familial cardiac arrhythmias.
  • Long QT Syndrome
  • Hypertrophic Cardiomyopathy
  • Arrhythmogenic Right Ventricular Dysplasia
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*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Unknown status
300
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December 2011
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Inclusion Criteria:

  • Patients with a history of syncope, abnormal ECG and suspicion of an arrhythmogenic disease
  • Patients with long QT syndrome
  • Patients with short QT syndrome, shortened QT intervals, borderline shortened QT intervals
  • Patients with Brugada syndrome
  • Patients with hypertrophic cardiomyopathy
  • Patients with arrhythmogenic right ventricular dysplasia

Exclusion Criteria:

  • Inability to understand study protocol
Sexes Eligible for Study: All
Child, Adult, Older Adult
No
Contact information is only displayed when the study is recruiting subjects
Germany
 
 
NCT00221832
0261.5
No
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Prof. C. Wolpert, I. Department of Medicine-Cardiology, University Hospital Mannheim, . Department of Medicine-Cardiology, University Hospital Mannheim
Heidelberg University
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Study Director: Martin Borggrefe, Prof., MD I. Department of Medicine-Cardiology
Heidelberg University
October 2003