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High-intensity Exercise Training in Patients With Post-infarction Heart Failure

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00218933
First Posted: September 22, 2005
Last Update Posted: February 9, 2017
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Norwegian University of Science and Technology
September 20, 2005
September 22, 2005
February 9, 2017
October 2001
September 2005   (Final data collection date for primary outcome measure)
Remodelling of heart function and structure [ Time Frame: 3 months ]
Remodelling of heart function and structure
Complete list of historical versions of study NCT00218933 on ClinicalTrials.gov Archive Site
Improved endothelial and skeletal muscle as well as quality of life [ Time Frame: 3 months ]
Improved endothelial and skeletal muscle as well as quality of life
Not Provided
Not Provided
 
High-intensity Exercise Training in Patients With Post-infarction Heart Failure
Anti-remodeling Effect of High-intensity Interval Training in Patients With Post-infarction Heart Failure on Optimal Treatment

Introduction: Moderate-intensity endurance-training is known to reduce symptoms, increase exercise tolerance, and improve quality of life in patients with chronic heart failure. The training benefits have mainly been attributed to adaptations in the peripheral circulation and skeletal muscle rather than to adaptations in cardiac performance. However attenuation of left ventricular (LV) remodelling has been documented in some studies. The effects of high- vs. moderate exercise-intensity on LV-remodelling and endothelial function in patients with post-infarction heart failure are not definitively established and were studied in the present study.

Methods: Patients with post-infarction heart failure (45-87 yrs, 22-males, 5-females, all received b-blockers and ACE-inhibitors, EF 29%, peak oxygen uptake 13 ml/kg/min) were randomized to 12-weeks, 2-3 times per week, of either moderate exercise-intensity (70% of peak heart rate), high-intensity interval-training (95% of peak heart rate) or to a control group that received advise from their regular doctors. Patients in the two exercise-groups covered similar distance on the treadmill at each exercise-session so that only exercise-intensity differed; i.e. the duration of exercise was longer in the moderate-intensity group. Ultrasound was used to assess LV-dimension and function (including Tissue Doppler Imaging, TDI) and endothelial function in the brachial-artery.

Not Provided
Interventional
Not Provided
Allocation: Randomized
Intervention Model: Factorial Assignment
Masking: Single (Outcomes Assessor)
Primary Purpose: Treatment
  • Heart Failure
  • Myocardial Infarction
  • Behavioral: Moderate intensity exercise training
    12-weeks, 2-3 times per week moderate exercise-intensity (70% of peak heart rate)
  • Behavioral: High intensity exercise training
    12-weeks, 2-3 times per week high-intensity interval-training (95% of peak heart rate)
  • Active Comparator: moderate exercise training
    Intervention: Behavioral: Moderate intensity exercise training
  • Experimental: high intensity exercise training
    Intervention: Behavioral: High intensity exercise training
  • No Intervention: controls
Wisløff U, Støylen A, Loennechen JP, Bruvold M, Rognmo Ø, Haram PM, Tjønna AE, Helgerud J, Slørdahl SA, Lee SJ, Videm V, Bye A, Smith GL, Najjar SM, Ellingsen Ø, Skjaerpe T. Superior cardiovascular effect of aerobic interval training versus moderate continuous training in heart failure patients: a randomized study. Circulation. 2007 Jun 19;115(24):3086-94. Epub 2007 Jun 4.

*   Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline.
 
Completed
27
September 2005
September 2005   (Final data collection date for primary outcome measure)

Inclusion Criteria:

Post-infarction heart failure and optimal treatment (ACE-inhibitors, Beta-blockade)

Exclusion Criteria:

Not able to walk on a treadmill, unstable angina, participating in another experiment, serious arrhythmia

Sexes Eligible for Study: All
30 Years and older   (Adult, Senior)
No
Contact information is only displayed when the study is recruiting subjects
Norway
 
 
NCT00218933
HFEX-1
No
Not Provided
Not Provided
Norwegian University of Science and Technology
Norwegian University of Science and Technology
Not Provided
Principal Investigator: Ulrik Wisloff, Ph.D Norwegian University of Science and Technology
Norwegian University of Science and Technology
February 2017

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP