Comment Period Extended to 3/23/2015 for Notice of Proposed Rulemaking (NPRM) for FDAAA 801 and NIH Draft Reporting Policy for NIH-Funded Trials

High-Intensity Exercise Training in Patients With Post-Infarction Heart Failure

This study has been completed.
Information provided by:
Norwegian University of Science and Technology Identifier:
First received: September 20, 2005
Last updated: October 23, 2008
Last verified: August 2008

September 20, 2005
October 23, 2008
October 2001
Not Provided
Remodelling of heart function and structure
Same as current
Complete list of historical versions of study NCT00218933 on Archive Site
Improved endothelial and skeletal muscle as well as quality of life
Same as current
Not Provided
Not Provided
High-Intensity Exercise Training in Patients With Post-Infarction Heart Failure
Anti-Remodeling Effect of High-Intensity Interval Training in Patients With Post-Infarction Heart Failure on Optimal Treatment

Introduction: Moderate-intensity endurance-training is known to reduce symptoms, increase exercise tolerance, and improve quality of life in patients with chronic heart failure. The training benefits have mainly been attributed to adaptations in the peripheral circulation and skeletal muscle rather than to adaptations in cardiac performance. However attenuation of left ventricular (LV) remodelling has been documented in some studies. The effects of high- vs. moderate exercise-intensity on LV-remodelling and endothelial function in patients with post-infarction heart failure are not definitively established and were studied in the present study.

Methods: Patients with post-infarction heart failure (45-87 yrs, 22-males, 5-females, all received b-blockers and ACE-inhibitors, EF 29%, peak oxygen uptake 13 ml/kg/min) were randomized to 12-weeks, 2-3 times per week, of either moderate exercise-intensity (70% of peak heart rate), high-intensity interval-training (95% of peak heart rate) or to a control group that received advise from their regular doctors. Patients in the two exercise-groups covered similar distance on the treadmill at each exercise-session so that only exercise-intensity differed; i.e. the duration of exercise was longer in the moderate-intensity group. Ultrasound was used to assess LV-dimension and function (including Tissue Doppler Imaging, TDI) and endothelial function in the brachial-artery.

Not Provided
Phase 1
Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Factorial Assignment
Masking: Single Blind
Primary Purpose: Treatment
  • Heart Failure
  • Myocardial Infarction
  • Exercise Training
Behavioral: Exercise training
Not Provided
Not Provided

*   Includes publications given by the data provider as well as publications identified by Identifier (NCT Number) in Medline.
September 2005
Not Provided

Inclusion Criteria:

Post-infarction heart failure and optimal treatment (ACE-inhibitors, Beta-blockade)

Exclusion Criteria:

Not able to walk on a treadmill, unstable angina, participating in another experiment, serious arrhythmia

30 Years and older
Not Provided
Contact information is only displayed when the study is recruiting subjects
Not Provided
Norwegian University of Science and Technology
Not Provided
Principal Investigator: Ulrik Wisloff, Ph.D Norwegian University of Science and Technology
Norwegian University of Science and Technology
August 2008

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP