Comment Period Extended to 3/23/2015 for Notice of Proposed Rulemaking (NPRM) for FDAAA 801 and NIH Draft Reporting Policy for NIH-Funded Trials

Childhood Origins of Asthma (COAST)

This study is ongoing, but not recruiting participants.
Information provided by (Responsible Party):
University of Wisconsin, Madison Identifier:
First received: September 12, 2005
Last updated: December 1, 2014
Last verified: December 2014

September 12, 2005
December 1, 2014
October 1998
May 2018   (final data collection date for primary outcome measure)
Evaluate the children longitudinally for the inception and progression of asthma. [ Time Frame: Birth through puberty. ] [ Designated as safety issue: No ]
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Complete list of historical versions of study NCT00204841 on Archive Site
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Childhood Origins of Asthma (COAST)
Rhinovirus Infection and Asthma in Childhood and Adolescents

Although asthma is likely to be a heterogeneous disease or syndrome, three factors and/or events repetitively emerge for their ability to significantly influence asthma inception in the first decade of life: immune response aberrations, which appear to be defined best by the concept of cytokine dysregulation; lower respiratory tract infections (in particular RSV); and some form of gene by environment interaction that needs to occur at a critical time period in the development of the immune system or the lung. It remains to be firmly established, however, how any one or all of these factors, either independently or interactively, influence the development of childhood asthma. Thus, our efforts to determine and define the importance of these three factors to asthma pathogenesis are the focus and goal of this current grant application.

No more description necessary.

Observational Model: Cohort
Time Perspective: Prospective
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Retention:   Samples With DNA

nasal mucus samples, cord blood, peripheral blood samples, nasal cell brushing samples, cell lines

Non-Probability Sample

High risk birth cohort of children (one or both parents have allergies and/or asthma).

  • Asthma
  • Allergy
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*   Includes publications given by the data provider as well as publications identified by Identifier (NCT Number) in Medline.
Active, not recruiting
May 2018
May 2018   (final data collection date for primary outcome measure)

Inclusion Criteria:

  • children who had one or more parent with a history of allergy or asthma

Exclusion Criteria:

  • pre term infants
  • low birth weight infants
  • respiratory distress at birth
up to 2 Minutes
Contact information is only displayed when the study is recruiting subjects
United States
1998-129, P01HL070831
University of Wisconsin, Madison
University of Wisconsin, Madison
  • National Institutes of Health (NIH)
  • National Heart, Lung, and Blood Institute (NHLBI)
Principal Investigator: Robert F Lemanske, Jr., MD University of Wisconsin, Madison
University of Wisconsin, Madison
December 2014

ICMJE     Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP